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Congmujingnosides B-G,triterpene saponins from the stem of Aralia chinensis and their protective effects against H2O2-induced myocardial cell injury |
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| Authors: | Wen Zhang Nailiang Zhu Meigeng Hu Shichun Yu Zhonghao Sun Haifeng Wu |
| Institution: | 1. Key Laboratory of Bioactive Substances and Resource Utilization of Chinese Herbal Medicine, Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of Efficacy Evaluation of Chinese Medicine against Glycolipid Metabolic Disorders, State Administration of Traditional Chinese Medicine, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China;2. School of Pharmacy, Ahhui University of Traditional Chinese Medicine, Hefei, China;3. School of Pharmacy, Ahhui University of Traditional Chinese Medicine, Hefei, China |
| Abstract: | Phytochemical investigation of the stem of Aralia chinensis yielded six new oleanane-type triterpene saponins named as congmujingnosides B-G (1–6). The new ones were elucidated on the basis of the chemical and spectroscopic analysis. Protective effects of compounds 1?6 were tested against H2O2-induced H9c2 cardiomyocyte injury, and the data showed that compounds 1 and 5 had significant cell-protective effects. No significant DPPH radical scavenging activity was observed for compounds 1?6. |
| Keywords: | Aralia chinensis triterpene saponins cardiomyocyte oxidative injury DPPH radical scavenging activity |