Penicillilactone A,a novel antibacterial 7-membered lactone derivative from the sponge-associated fungus Penicillium sp. LS54 |
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Authors: | Yong Liu Fang Fang |
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Institution: | Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, China |
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Abstract: | One novel 7-membered lactone derivative, penicillilactone A (1), together with two known compounds, rugulosin A (2) and rugulosin (3) were isolated from the sponge-derived fungus Penicillium sp. LS54. Their structures were elucidated on the basis of spectroscopic analysis and comparison with literature data. Remarkably, penicillilactone A (1) is the first natural product containing a 7-membered lactone ring fused with a furan core. Penicillilactone A (1) exhibited moderate antibacterial activity against aquatic pathogen Vibrio harveyi with an MIC value of 8 μg/mL. |
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Keywords: | Penicillium sp sponge-associated fungi lactone derivative antibacterial activity |
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