Aromatic compounds produced by endophytic fungi isolated from red alga Asparagopsis taxiformis - Falkenbergia stage |
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| Authors: | Rebeca P Medina Angela R Araujo Raymond J Andersen Marcos A Soares Fabio de A Silva |
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| Institution: | 1. Núcleo de Bioensaios, Biossíntese e Ecofisiologia de Produtos Naturais (NuBBE), Departamento de Química Organica, Instituto de Química, UNESP - Univ. Estadual Paulista, Araraquara, Brazil;2. Department of Chemistry and Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada;3. Instituto de Biociências, Universidade Federal de Mato Grosso, Cuiabá, Brazil |
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| Abstract: | Endophytic fungi were isolated from red alga Asparagopsis taxiformis - Falkenbergia stage, collected from the Brazilian coast, and were identified as Annulohypoxylon stygium (AT-03) and A. yungensis (AT-06) based on their macro/micromorphological and molecular features. Bioassay-guided fractionation of the EtOAc extract from laboratory cultures of both strains yielded known compounds pyrogallol from A. stygium, (3R)-scytalone and (3R,4R)-4-hydroxy-scytalone from A. yungensis. Pyrogallol was active against methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli strains. An inactive fraction from A. stygium afforded two additional compounds, (3R,4R)-3,4,5-trihydroxy-1-tetralone and tyrosol. Optically active compounds had their stereochemistry determined by circular dichroism (CD) spectroscopy. |
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| Keywords: | Marine red alga Asparagopsis taxiformis endophytic fungus Annulohypoxylon antimicrobial activity aromatic compounds |
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