Markhacanasin C,cycloartane triterpenoid from the leaves of Markhamia stipulata var. canaense V.S. Dang |
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| Authors: | Trong Nghia Ngo Cong Thin Vo Nguyen Kim Tuyen Pham Nhat Minh Phan Trong Dat Bui Quoc Luan Ngo |
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| Institution: | 1. Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Viet Nam;2. Faculty of Environment and Natural Resources, Kien Giang University, Kien Giang City, Viet Nam;3. Faculty of Environmental Sciences, Sai Gon University, Ho Chi Minh City, Viet Nam;4. Hoa Hoi High School, Xuyen Moc, Ba Ria-Vung Tau Province, Viet Nam;5. Bioactive Compounds Laboratory, Institute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Viet Nam;6. School of Education, Can Tho University, Can Tho City, Viet Nam |
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| Abstract: | One new cycloartane triterpenoid, named markhacanasin C (1), together with three known triterpenoids, oleanolic acid (2), ursolic acid (3) and 6β,19α-dihydroxyursolic acid (4) were isolated by various chromatographic methods from the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S. Dang leaves. Among them, 4 was reported for the first time from the genus Markhamia, while 2 and 3 were found for the first time from this species. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR experiments. The cytotoxicity of isolated compounds (3 and 4) against three human cancer cell lines (HeLa, HepG2, and MCF-7) were evaluated. At the concentration of 100 μg/mL, 3 exhibited significant cytotoxic activity (86.36 ± 3.69%). |
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| Keywords: | Markhamia stipulata Bignoniaceae markhacanasin C cytotoxic activity |
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