12β-Acetyloxyperforatin,a New Limonoid from Harrisonia Perforata |
| |
| Authors: | Peng-Yan Gui Xiao-Hui Yan Wen-Juan Yuan Yuan-Liang Ma Xiao Ding Shuai Liu |
| |
| Institution: | 1. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, China;2. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China;3. College of Forestry, Southwest Forestry University/Key Laboratory of Forest Disaster Warning and Control of Yunnan Province, China;4. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, China;5. Yunnan Institute for Food and Drug control, Kunming, Yunnan, China |
| |
| Abstract: | A new A, D-seco limonoid, named 12-acetyloxyperforatin (1), along with three known ones, were isolated from the leaves of Harrisonia perforata. Their structures were elucidated on the basis of spectroscopic analysis, including extensive NMR techniques and computational modelling. These compounds showed no inhibitory activity against the 11β-HSD1 enzyme. |
| |
| Keywords: | Harrisonia perforata limonoid 12β-Acetyloxyperforatin computational modelling |
|
|
