Antimicrobial mechanism of copper (II) 1,10-phenanthroline and 2,2′-bipyridyl complex on bacterial and fungal pathogens |
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| Institution: | 1. Department of Chemistry, A.V.V.M. Sri Pushpam College (Autonomous), Poondi 613 503, Thanjavur District, Tamil Nadu, India;2. Department of Microbiology, School of Life Sciences, Bharathidasan University, Tiruchirapalli 620 024, Tamil Nadu, India;3. P.G. & Research Department of Botany & Microbiology, A.V.V.M. Sri Pushpam College (Autonomous), Poondi 613 503, Thanjavur District, Tamil Nadu, India |
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| Abstract: | Copper based metallo drugs were prepared and their antibacterial, antifungal, molecular mechanism of Cu(SAla)Phen]·H2O and Cu(SAla)bpy]·H2O complexes were investigated. The Cu(SAla)Phen]·H2O and Cu(SAla)bpy]·H2O were derived from the Schiff base alanine salicylaldehyde. Cu(SAla)Phen]·H2O showed noteworthy antibacterial and antifungal activity than the Cu(SAla)bpy]·H2O and ligand alanine, salicylaldehyde. The Cu(SAla)Phen]·H2O complex showed significant antibacterial activity against Salmonella typhi, Staphylococcus aureus, Salmonella paratyphi and the antifungal activity against Candida albicans and Cryptococcus neoformans in well diffusion assay. The mode of action of copper (II) complex was analyzed by DNA cleavage activity and in silico molecular docking. The present findings provide important insight into the molecular mechanism of copper (II) complexes in susceptible bacterial and fungal pathogens. These results collectively support the use of Cu(SAla)Phen]·H2O complex as a suitable drug to treat bacterial and fungal infections. |
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| Keywords: | Copper (II) complex Bacteria Fungi DNA Molecular docking |
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