CuSO4/sodium ascorbate catalysed synthesis of benzosuberone and 1,2,3-triazole conjugates: Design,synthesis and in vitro anti-proliferative activity |
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| Authors: | CHB Praveena Devi K Vijay B Hari Babu Syed Farooq Adil M Mujahid Alam M Vijjulatha Mohd Bismillah Ansari |
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| Institution: | 1. Department of Pharmaceutical Chemistry, University College of Pharmaceutical Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Quest International University Perak, 30250 Ipoh, Malaysia;3. Department of Chemistry, University College of Sciences, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur 522510, India;4. Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia;5. Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia;6. Department of Chemistry, Osmania University, Hyderabad, Telangana, India;7. SABIC Technology & Innovation Centre, Saudi Basic Industries Corporation (SABIC), Riyadh 11551, Saudi Arabia |
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| Abstract: | A novel series of conjugates of benzosuberone and 1,2,3-triazole i.e. 3-(4-phenyl-1H-1,2,3-triazol-1-yl)propyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo7]annulene-8-carboxylic acids (8a-j) were synthesized in good to excellent yields catalysed by CuSO4 under milder reaction conditions and evaluated for their anti-proliferative activity. The structural elucidation of the prepared compounds was carried out using IR, 1H NMR, 13C NMR and Mass spectral analysis. The newly synthesized derivatives (8a-j) were evaluated for their anti-proliferative activity against four human cell lines and the novel derivatives showed moderate to excellent activity. The obtained results suggest that these compounds can be considered as new hits for anti-proliferative drug development programme and further SAR studies can help obtain better anticancer agents. |
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| Keywords: | Corresponding author Benzosuberone Triazole derivative Anti-proliferative activity Molecular docking |
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