Unexpected complexation reaction during analysis of proteins using laser desorption spray post-ionization mass spectrometry |
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| Authors: | Liu Jia Zhang Chengsen Sun Jiamu Luo Hai |
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| Institution: | Beijing National Laboratory for Molecular Sciences, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, China. |
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| Abstract: | We describe complexation reactions of insulin and other proteins with metal ions generated from the substrate surface by laser irradiation in laser desorption spray post-ionization mass spectrometry (LDSPI-MS). This particular type of complexation reaction in LDSPI-MS was investigated for the first time, which indicated that the mechanistic process of LDSPI-MS might be much more complicated than that proposed before for similar methods. |
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