Chemically-modified nanopores for sensing |
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Authors: | Rbert E Gyurcsnyi |
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Institution: | aDepartment of Inorganic and Analytical Chemistry, Budapest University of Technology and Economics and Research Group for Technical Analytical Chemistry of the Hungarian Academy of Sciences, Szt. Gellért tér 4, 1111 Budapest, Hungary |
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Abstract: | Sensing with chemically-modified nanopores is an emerging field that is expected to have major impact on bioanalysis and fundamental understanding of nanoscale chemical interactions down to the single-molecule level. The main strength of nanopore sensing is that it implies the prospect of label-free single-molecule detection by taking advantage of the built-in transport-modulation-based amplification mechanism. At present, fabrication and application of solid-state nanopores are becoming the focus of attention because, compared with their biological counterparts, they offer greater flexibility in terms of shape, size, and surface properties, as well as superior robustness. A breakthrough in label-free nanopore sensing for real-world applications is therefore expected from implementing solid-state nanopores, an area that is still developing. Without claiming comprehensiveness, the focus of this review comprises recent results and trends in nanopore-based sensing (i.e. emerging technologies for fabricating solid-state nanopores, their chemical functionalization, and detection methods for quantitative analysis). |
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Keywords: | Affinity-type bioassay Bioanalysis Biosensing Chemically-modified nanopore Chemical sensing Label-free single-molecule detection Nanopore sensing Resistive-pulse technique Solid-state nanopore Transport modulation |
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