Synthesis, Structure Characterization and Biological Activity of Adenine Salt of 12-Phosphotungstic Acid

A novel adenine(Ade) salt of 12-phosphotungstic acid was synthesized and characterized by elemental analyses, IR, 1H NMR, CV and single crystal X-ray diffraction. The compound crystallized in a triclinic system with a space group P1 and a=1.3108(3) nm, b=1.3515(3) nm, c=1.3870(3) nm, V=2.0217(7) nm3, Z=1, R1=0.0391, wR2=0.0959. The structure unit of the complex was constructed from HPW12*O40]-, (C5H6N5) and C3H7NO, which further extends to form a novel three-dimensional host-guest network via hydrogen-bonding interactions. The anti-tumor activity of the compound was examined in two human tumor cell lines in vitro.