| Halodemetallation of (Z)-1-[2-(Triarylstannyl)vinyl]-cyclooctanol and Correlation of Proton Chemical Shift with Electronegativity |
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| 作者单位： | REN Yu-jie,YU Li-mei,YANG Xue-feng(Department of Chemistry, Dalian University of Technology, Dalian 116024, P. R. China);CHEN Hui-lin(Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China);BAI Ri-Xia(Dalian Nationality College, Dalian 116600, P. R. China)
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| 摘 要： | IntroductionOrganotin compounds have attracted attentionas an optimal model for antitumour agents due tothe function of the interesting intramolecularO→Sn coordination1,2 ] . Our recent concern hasbeen focused on the preparation of ( Z) - 1 - 2 -( triarylstannyl) vinyl]- cyclooctanol3 ] .In order tofind more appropriate compounds used asanticancer agents and explore the effect of thecoordinate O→ Sn interaction to the antitumoractivity,the new compounds werehalodemetallated and characte…
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Halodemetallation of (Z)-1-[2-(Triarylstannyl)vinyl]-cyclooctanol and Correlation of Proton Chemical Shift with Electronegativity |
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| Authors: | REN Yu-jie YU Li-mei YANG Xue-feng CHEN Hui-lin BAI Ri-Xia |
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| Abstract: | Introduction Organotin compounds have attracted attention as an optimal model for antitumour agents due to the function of the interesting intramolecular O→Sn coordination1,2]. Our recent concern has been focused on the preparation of (Z)-1-2-(triarylstannyl)vinyl]-cyclooctanol3]. In order to find more appropriate compounds used as anticancer agents and explore the effect of the coordinate O→Sn interaction to the antitumor activity, the new compounds were halodemetallated and characterized. During the course of the process, some linear correlations between proton chemical shifts and the sum of the electronegativities of the tin substituents of halogens were found for the first time. |
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| Keywords: | Organotin Halodemetallation Correlation Chemical shift Electronegativity |
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