Novel Efficient Method for Synthesis of N_(1,4)-Disubstituted-1,4-benzodiazepine-2,5-diones |
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| Authors: | WANG Qiu-yan YU Jing-jun LU Cui-fen CHEN Zu-xing YANG Gui-chun Key Laboratory for the Synthesis Application of Organic Functional Molecules of Ministry of Education School of Chemistry Chemical Engineering Hubei University Wuhan P R China |
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| Institution: | Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China |
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| Abstract: | A novel and efficient method was developed for the liquid-phase synthesis of N1,4-disubstituted-benzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing esterification,Ulmn reaction,acylation,alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%. |
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| Keywords: | 1 4-Benzodiazepine-2 5-dione Liquid-phase Dipeptides |
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