Synthesis and Biological Evaluation of Novel Tricyclic Oximino Derivatives as Antitumor Agents |
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| Authors: | Shu-chun GUO Yan-fang ZHAO Rong-dong LI Li-jun XIE You-bin YANG Ping GONG |
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| Institution: | aSchool of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China |
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| Abstract: | A series of novel alkylthio/sulfinyl-8H-thieno2,3-b]pyrrolizin-8-oximino derivatives Ⅴ1-Ⅷ15 were designed and synthesized as antitumor agents. Their structures were confirmed using IR, 1H NMR, elemental analysis,and MS. The antitumor activities of all the target compounds were tested by the MTT method in vitro against Bel-7402,HT-1080, SGC-7901, and A549 Cell Lines. Among them, compound Ⅵ9 displayed a promising antitumor activity superior to that of Cisplatin. |
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| Keywords: | Thieno[2 3-b] pyrrolizine Synthesis Antitumor activity |
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