Ionic Liquid-based Microwave-assisted Liquid-liquid Microextraction and High Performance Liquid Chromatography Determination of Sulfonamides from Animal Oils |
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Authors: | FENG Xu-dong LIANG Fang-hui SU Rui WU Li-jie LI Xue-yuan WANG Xing-hua ZHANG Han-qi YU Ai-min |
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Institution: | 1. College of Chemistry, Jilin University, Changchun 130012, P. R. China;
2. Department of Pharmacy, Changchun Medical College, Changchun 130117, P. R. China |
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Abstract: | The authors performed ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME) coupled with high performance liquid chromatographic separation for the determination of 6 sulfonamides (SAs) from animal oils. The target analytes were extracted from animal oil samples with sodium hydroxide solution containing 1-butyl-3-methylimidazolium tetrafluoroborateand as the extraction solvent under microwave irradiation. The experimental parameters of the IL-based MALLME, including types of ILs, volume of IL, amount of ion-pairing agent(NH4PF6), pH value of sample solution, and extraction temperature and time were evaluated. The limits of detection and quantification obtained were in a range of 0.4―0.5 μg/kg and a range of 1.2―1.8 μg/kg, respectively. The accuracy of the method was evaluated by analyzing five spiked animal oil samples at two fortified levels(5 and 50 μg/kg), and the recoveries of SAs varied from 81.4% to 114.5% with relative standard deviations ranging from 0.8% to 9.0%. |
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Keywords: | Ionic liquid-based microwave-assisted liquid-liquid microextraction(IL-based MALLME) High performance liquid chromatography(HPLC) Sulfonamide Animal oil |
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