| Tobacco-specific Carcinogen 4- （Methylnitrosoamino） -1- （3-pyridyl） - 1-butanone（NNK） Activating ERK1/2 MAP Kinases and Stimulating Proliferation of Human Mammary Epithelial Cells |
| |
| 作者姓名： | CHEN Zhi-bo AN Yang WANG Zhe ZHANG Bo-xun LIU Lan-ying |
| |
| 作者单位： | [1]College of Life Science, Jilin University, Changchun 130021, P. R. China [2]College of Life Science and Engineering, Qiqihar University, Qiqihar 161000, P. R. China [3]Department of Internal Medicine of Digestion, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China |
| |
| 基金项目： | Supported by the Natural Science Foundation of Jilin Province（ No. 200305-50-1 ）. |
| |
| 摘 要： | Cigarette smoking is correlated with the development of various cancers. 4- （Methylnitresoamino） -1- （3-pyridyl） - 1-butanone（NNK） is one of the major tobacco-specific carcinogens in the cigarette smoke, which increases the risk of breast cancer. In the present study, it was demonstrated that NNK rapidly activated ERK1 and ERK2 MAP kinases in human normal mammary epithelial cells. It was found that there are two different routes for the activation of ERK1/2 with NNK. One is from nicotinic receptor nAchR to MEK1/2, and the other is from tyrosine kinase containing receptor to MEK1/2. The tobacco-specific carcinogen NNK shows a strong proliferative effect on normal human mammary epithelial cells and cancer mammary epithelial cells.
|
| 关 键 词： | 烟草 抽烟 特异性致癌物质 人乳腺上皮细胞 细胞增殖 NNK ERK1/2MAP激酶 烟碱受体 酪氨酸激酶 信号传导通路 |
| 收稿时间： | 2005-12-31 |
Tobacco-specific Carcinogen 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK) Activating ERK1/2 MAP Kinases and Stimulating Proliferation of Human Mammary Epithelial Cells |
| |
| CHEN Zhi-bo AN Yang WANG Zhe ZHANG Bo-xun LIU Lan-ying.Tobacco-specific Carcinogen 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK) Activating ERK1/2 MAP Kinases and Stimulating Proliferation of Human Mammary Epithelial Cells[J].Chemical Research in Chinese University,2007,23(1):76-80. |
| |
| Authors: | CHEN Zhi-bo AN Yang WANG Zhe ZHANG Bo-xun LIU Lan-ying |
| |
| Institution: | 1. College of Life Science, Jilin University, Changchun 130021, P. R. China;2. College of Life Science and Engineering, Qiqihar University, Qiqihar 161000, P. R. China;3. Department of Internal Medicine of Digestion, China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China |
| |
| Abstract: | Cigarette smoking is correlated with the development of various cancers. 4-(Methylnitrosoamino)-1-(3-pyridyl)-1-butanone(NNK) is one of the major tobacco-specific carcinogens in the cigarette smoke, which increases the risk of breast cancer. In the present study, it was demonstrated that NNK rapidly activated ERK1 and ERK2 MAP kinases in human normal mammary epithelial cells. It was found that there are two different routes for the activation of ERK1/2 with NNK. One is from nicotinic receptor nAchR to MEK1/2, and the other is from tyrosine kinase containing receptor to MEK1/2. The tobacco-specific carcinogen NNK shows a strong proliferative effect on normal human mammary epithelial cells and cancer mammary epithelial cells. |
| |
| Keywords: | Mammary epithelial cells NNK ERK MAPK Nicotinic receptor nAehR Tyrosine kinase Signaling pathway Carcinogen Cell proliferation |
| 本文献已被 CNKI 维普 ScienceDirect 等数据库收录！ |
