A Novel Coumarin-based Fluorescence Chemosensor for Fe^3＋

A novel coumarin derivative7-diethylamino-2-oxo-2H-chromene-3-carboxylic acid（6-amino-pyridin2-yl）-amide,CFe1] has been synthesized and its potential application as a chemosensor for the detection of metal ions has been further investigated.The responses of CFe1 to Fe^3＋ were studied by fluorescence emission spectrometry in the presence of other metal ions such as Al^3＋,Ba^2＋,Ca^2＋,Co^3＋,Cr^3＋,Cu^2＋,Fe^2＋,Hg^2＋,Mg^2＋,Mn^2＋,Na^＋,Ni^＋,Pb^2＋,Zn^2＋,K^＋,and Ag^＋.CFe1 showed a good selectivity for Fe^3＋ with fast response,a wide pH span of 3.3-9.18,and a large Stocks shift.CFe1 in the presence of Fe^3＋ and ethylene diamine tetraacetic acid（EDTA） makes the blue solution fade to colorless,which is due to the formation of CFe1-Fe^3＋ complex instead of any catalytic action of Fe^3＋.Furthermore,the imaging of Fe^3＋ in cultured single mice microglia cells was realized with the aid of CFe1,indicating that CFe1 has a great potential to be used as promising models for the future design of novel and robust chemosensor for metal ion detection in the field of biomedical and environmental analyses.

A Novel Coumarin-based Fluorescence Chemosensor for Fe3+

A novel coumarin derivative7-diethylamino-2-oxo-2H-chromene-3-carboxylic acid(6-amino-pyridin- 2-yl)-amide, CFe1] has been synthesized and its potential application as a chemosensor for the detection of metal ions has been further investigated. The responses of CFe1 to Fe³⁺ were studied by fluorescence emission spectrometry in the presence of other metal ions such as Al³⁺, Ba²⁺, Ca²⁺, Co³⁺, Cr³⁺, Cu²⁺, Fe²⁺, Hg²⁺, Mg²⁺, Mn²⁺, Na⁺, Ni⁺, Pb²⁺, Zn²⁺, K⁺, and Ag⁺. CFe1 showed a good selectivity for Fe³⁺ with fast response, a wide pH span of 3.3-9.18, and a large Stocks shift. CFe1 in the presence of Fe³⁺ and ethylene diamine tetraacetic acid(EDTA) makes the blue solution fade to colorless, which is due to the formation of CFe1-Fe³⁺ complex instead of any catalytic action of Fe³⁺. Furthermore, the imaging of Fe³⁺ in cultured single mice microglia cells was realized with the aid of CFe1, indicating that CFe1 has a great potential to be used as promising models for the future design of novel and robust chemosensor for metal ion detection in the field of biomedical and environmental analyses.