Asymmetric Synthesis of (R)-and (S)-Moprolol |
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| Authors: | WANG Zhao-yang WANG Yan SUN Li-wen ZHU Jin-tao |
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| Institution: | WANG Zhao-yang1,WANG Yan1,SUN Li-wen2 , ZHU Jin-tao1 1. Department of Chemistry,Zhejiang Sci-Tech University,Hangzhou 310018,P. R. China,2. Institute of Materia Medica,Zhejiang Academy of Medical Science,Hangzhou 310013 |
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| Abstract: | A simple and effective procedure for the enantioselective synthesis of (R)-and (S)-moprolol was described.The key step was the asymmetric synthesis of enantiopure (R)-and (S)-guaifenesin,which were synthesized from enantioenriched (R)-3-chloro-1,2-propanediol and (S)-epichlorohydrin via kinetics of hydrolysis resolution of racemic epichlorohydrin by chiral Salen-CoIIII complex.The e.e.values of both the optical compounds were above 98%,and the chemical structures of the target compounds were confirmed by 1H NMR,13C NMR,IR,and MS. |
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| Keywords: | (R)-and (S)-Moprolol (R)-and (S)-Guaifenesin Asymmetric synthesis |
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