| Design, Synthesis, and Activities of Novel Derivatives of Isophthalamide and Benzene-1,3-disulfonamide |
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| 作者姓名： | LIU Xiu-jie WANG Song-qing ZHANG jing ZHANG Feng-xia LI Gui-zhu WANG Bao-jie SHAO Ying-lu ZHANG Li-guang FANG Lin CHENG Mao-sheng |
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| 作者单位： | LIU Xiu-jie 1，3，WANG Song-qing 2，ZHANG Jing 1，ZHANG Feng-xia 1，LI Gui-zhu 1，WANG Bao-jie 1，SHAO Ying-lu 1，ZHANG Li-guang 1，FANG Lin 1 and CHENG Mao-sheng 11. The College of Pharmaceutical Engineering，Shenyang Pharmaceutical University，Shenyang 110016，P.R. China;2. The College of Pharmaceutical and Biotechnology，Tianjin University，Tianjin 300072，P.R. China;3. The School of Biology and Chemistry，Tianjin University of Technology，Tianjin 300191，P.R. China |
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| 摘 要： | Introduction Themeritsofantiplatelettherapyforthepreven tionofthrombosisincardiovasculardiseaseareevi dent.Meta analysisresultshaveshownthatsecondary preventionbyantiplateletaggregationagentscanreduce theriskofnonfatalmyocardialinfarction(MI)and strokeby2…
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| 关 键 词： | 凝血噁烷 抗血小板 合成 活性 异邻苯二酰胺 二磺酰胺 心血管病 |
| 文章编号： | 1005-9040（2006）-03-356-04 |
| 收稿时间： | 2005-03-18 |
Design, Synthesis, and Activities of Novel Derivatives of Isophthalamide and Benzene-1, 3-disulfonamide |
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| LIU Xiu-jie WANG Song-qing ZHANG jing ZHANG Feng-xia LI Gui-zhu WANG Bao-jie SHAO Ying-lu ZHANG Li-guang FANG Lin CHENG Mao-sheng.Design, Synthesis, and Activities of Novel Derivatives of Isophthalamide and Benzene-1,3-disulfonamide[J].Chemical Research in Chinese University,2006,22(3):356-359. |
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| Authors: | Xiu-jie LIU Song-qing WANG Jing ZHANG Feng-xia ZHANG Gui-zhu LI Bao-jie WANG Ying-lu SHAO Li-guang ZHANG Lin FANG Mao-sheng CHENG |
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| Institution: | aThe College of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;bThe College of Pharmaceutical and Biotechnology, Tianjin University, Tianjin 300072, P. R. China;cThe School of Biology and Chemistry, Tianjin University of Technology, Tianjin 300191, P. R. China |
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| Abstract: | Based on the antiplatelet aggregation mechanism and the bioisosterism principle of the reference drug picotamide, thirteen novel derivatives of arylamide and arylsulfonamide were designed and prepared. The biological activities of these derivatives were investigated. The chemical structures of the target compounds were confirmed by 1 H NMR and IR. The in vitro activities of antiplatelet aggregation of the thirteen target compounds were assessed by Born's method. Compounds 2b and 8h have significant antiplatelet aggregation activities, which are superior to the corresponding activity of Picotamide. |
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| Keywords: | Thromboxane Antiplatelet Isophthalamide Disulfonamide Synthesis |
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