| Trinuclear Metal Complexes Based on 1,10-Phenanthroline Derivates as Catalysts for Cleavage of a RNA-Model Substrate |
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| 作者姓名： | XU Xin-he LIN Hai LIN Hua-kuan |
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| 作者单位： | XU Xin-he1，LIN Hai2 and LIN Hua-kuan1 1.Department of Chemistry，2.Key Laboratory of Functional Polymer Materials of Ministry of Education，Nankai University，Tianjin 300071，P.R.China |
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| 基金项目： | Supported by the National Natural Science Foundation of China(Nos.20371028and20671052). |
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| 摘 要： | Two multidentate ligands 2,9-di6'-(2″-hydroxyl-3″-methoxyphenyl)-n-2',5'-diazahexyl]-1,10-phenanthroline(LA)and 2,9-di(6'-α-phenol-n-2',5'-diazahexyl)-1,10-phenanthroline(LB)were synthesized and fully characterized.Protonation of the ligands and the stability of the complexes of the ligands with divalent metal ions were investigated.The trinuclear metal complexes Cu(Ⅱ)and Zn(Ⅱ)] of the ligands were studied,as catalysts,for the transphosphorylation of the RNA-model substrate 2-hydroxypropyl-p-nitrophenyl phosphate(HPNP).The second-order rate constants of HPNP-hydrolysis catalyzed by M3L and M3LH-1 were obtained,which indicated that Zn3LBH-1 was the most efficient catalyst among them.The proposed mechanisms included the activation of the substrate via binding to the metal ions and intramolecular nucleophilic attack by the deprotonated C2-hydroxyl of HPNP.
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| 关 键 词： | 三核金属配合物 1 10-邻二氮杂菲 催化剂 RNA模型 分裂 |
| 收稿时间： | 19 November 2006 |
| 修稿时间： | 2006-11-19 |
Trinuclear Metal Complexes Based on 1,10-Phenanthroline Derivates as Catalysts for Cleavage of a RNA-Model Substrate |
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| XU Xin-he LIN Hai LIN Hua-kuan.Trinuclear Metal Complexes Based on 1,10-Phenanthroline Derivates as Catalysts for Cleavage of a RNA-Model Substrate[J].Chemical Research in Chinese University,2007,23(5):493-499. |
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| Authors: | Xin-he XU Hai LIN Hua-kuan LIN |
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| Institution: | aDepartment of Chemistry;bKey Laboratory of Functional Polymer Materials of Ministry of Education, Nankai University, Tianjin 300071, P. R. China |
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| Abstract: | Two multidentate ligands 2,9-di 6'-(2"-hydroxyl -3"-methoxyphenyl) -n-2',5'-diazahexyl ] -1,10-phenanthroline (LA) and 2,9 -di ( 6'-α-phenol-n-2', 5' -diazahexyl) - 1,10 - phenanthroline ( LB ) were synthesized and fully characterized. Protonation of the ligands and the stability of the complexes of the ligands with divalent metal ions were investigated. The trinuclear metal complexes Cu (Ⅱ) and Zn (Ⅱ)] of the ligands were studied, as catalysts, for the transphosphorylation of the RNA-model substrate 2-hydroxypropyl-p-nitrophenyl phosphate(HPNP). The second-order rate constants of HPNP-hydrolysis catalyzed by M3L and M3LH-1 were obtained, which indicated that Zn3LBH-1 was the most efficient catalyst among them. The proposed mechanisms included the activation of the substrate via binding to the metal ions and intramolecular nucleophilic attack by the deprotonated C2-hydroxyl of HPNP. |
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| Keywords: | Trinuclear metal complex 1 10-Phenanthroine derivate Catalyst Cleavage of RNA-model substrate |
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