Determination of Vitamin B1 in Pharmaceutical Preparations by Flow-injection Analysis with Biamperometric Detection |
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Authors: | LI Li-jun CHENG Hao ZHAO Chuan HU Xiao-ge |
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Institution: | 1. Department of Biological and Chemical Engineering, Guangxi University of Technology,Liuzhou 545006, P. R. China;
2. Institute of Analytical Science, Northwest University, Xi'an 710069, P. R. China |
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Abstract: | A new electrochemical method for the on-line determination of vitamin B1 is presented. Based on dead-stop endpoint biamperometry by using two platinum foil electrodes with an applied potential difference of 150 mV, vitamin B1can be oxidized by hexacyanoferrate ( Ⅲ ) in a sodium hydroxide medium via a reversible indicating couple Fe( CN)64-/Fe(CN)63-. The cell current is linear with the concentration of vitamin B1 in the concentration range of 4.0×10-6-1.0 × 10-3 mol/L with a detection limit of 8.0×10-7 mol/L(0. 27 μg/mL). Most familiar excipients,ions and vitamins do not interfere with the determination of vitamin B1. The method displays the advantages of simplicity, high efficiency( 180 samples/h), and high selectivity, and is suitable for the determination of vitamin B1 in pharmaceutical preparations. |
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Keywords: | Pharmaceutical analysis Biamperometry Vitamin B1 Flow-injection analysis |
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