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| 超高效液相色谱-串联质谱法测定牛奶和奶粉中6种聚醚类抗生素残留量 | |
| 引用本文： | 薄海波,雒丽丽,曹彦忠,星玉秀,庞国芳.超高效液相色谱-串联质谱法测定牛奶和奶粉中6种聚醚类抗生素残留量[J].分析化学,2009,37(8). |
| 作者姓名： | 薄海波 雒丽丽 曹彦忠 星玉秀 庞国芳 |
| 作者单位： | 1. 青海出入境检验检疫局,西宁,810000 2. 甘肃农业大学,兰州,730070 3. 秦皇岛出入境检验检疫局,秦皇岛,066002 4. 中国科学院西北高原生物研究所,西宁,810008 |
| 基金项目： | 国家标准2007年第七批制修订计划项目 |
| 摘 要： | 建立了用于检测牛奶和奶粉中拉沙洛菌素、莫能菌素、尼日利亚菌素、盐霉素、甲基盐霉素和马杜霉素铵6种聚醚类抗生素残留量的超高效液相色谱-串联质谱分析方法.用乙腈提取样品中的聚醚类抗生素,提取液经HLB固相萃取柱净化,采用超高效液相色谱分离,以电喷雾离子源正离子多反应监测模式进行质谱分析.6种抗生素在0.5～100.0 μg/L范围内均呈线性,相关系数r>0.99.在空白样品中添加6种聚醚类抗生素的回收率均在74.0%～98.5%之间; 精密度(RSD)4.8%～17.2%.牛奶中6种聚醚类抗生素检出限均为0.2 μg/L;奶粉中6种聚醚类抗生素检出限均为1.6 μg/kg. |
| 关 键 词： | 聚醚类抗生素 残留分析 超高效液相色谱-串联质谱 牛奶 奶粉 |
Determination of Six Polyether Antibiotics Residues in Milk and Milk Powder by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry |
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| BO Hai-Bo,LUO Li-Li,CAO Yan-Zhong,XING Yu-Xiu,PANG Guo-Fang.Determination of Six Polyether Antibiotics Residues in Milk and Milk Powder by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2009,37(8). | |
| Authors: | BO Hai-Bo LUO Li-Li CAO Yan-Zhong XING Yu-Xiu PANG Guo-Fang |
| Institution: | BO Hai-Bo2,LUO Li-Li3,CAO Yan-Zhong1,XING Yu-Xiu4,PANG Guo-Fang1 1(Qinhuangdao Entry and Exit Inspection and Quarantine Bureau,Qinhuangdao 066002)2(Qinghai Entry and Exit Inspection and Quarantine Bureau,Xining 810000)3(Gansu Agricultural University,Lanzhou 730030)4(Northwest Institute of Altiplano Biology,Chinese Academy of Sciences,Xining 810000) |
| Abstract: | A sensitive and selective method was developed for the determination of asalocid,monensin,nigericin,salinomycin,narasin and maduramicin ammonium residues in milk and milk powder.The polyether antibiotics in the test samples were extracted with acetonitrile.The extract was cleaned up with HLB solid phase extract column and analysis by ultra performance liquid chromatography-tandem mass spectrometry.Electrospray ionization was applied and operated in the positive ion mode.The calibration curves were good line... |
| Keywords: | Polyether antibiotics residue analysis ultra performance liquid chromatography tandem mass spectrometry milk milk powder |
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