| 血清一阶导数荧光光谱诊断早期恶性肿瘤 |
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| 引用本文： | 张荣斌,周培琛,林国春,李耀群.血清一阶导数荧光光谱诊断早期恶性肿瘤[J].分析化学,2007,35(12):1795-1797. |
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| 作者姓名： | 张荣斌 周培琛 林国春 李耀群 |
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| 作者单位： | 1. 厦门大学化学化工学院与现代分析科学教育部重点实验室,厦门,361005
2. 厦门大学物理与机电学院,厦门,361005 |
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| 基金项目： | 国家自然科学基金
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国家重点基础研究发展规划(973计划)
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福建省自然科学基金 |
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| 摘 要： | 利用Wistar大鼠接种恶性肉瘤模拟人患上癌症。取Wistar大鼠眼静脉血制备血清,并用乙醇简单处理得上层清液,扫描获得其一阶导数荧光光谱,确定上层清液原卟啉发射带(630 nm附近)的峰高,观察到健康Wistar大鼠与癌变大鼠的血清样存在明显差异,10例癌变样假阳性率为0,而20例正常样中仅有1例假阳性达到了恶性肿瘤早期诊断的目的。
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| 关 键 词： | 癌症 原卟啉 阶导数荧光光谱 血清 |
| 收稿时间： | 2007-05-14 |
| 修稿时间： | 2007-08-06 |
Cancer Diagnosis at Early Stage Using Serum Derivative Fluorescence Emission Spectra |
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| Zhang Rong-Bin,Zhou Pei-Chen,Lin Guo-Chun,Li Yao-Qun.Cancer Diagnosis at Early Stage Using Serum Derivative Fluorescence Emission Spectra[J].Chinese Journal of Analytical Chemistry,2007,35(12):1795-1797. |
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| Authors: | Zhang Rong-Bin Zhou Pei-Chen Lin Guo-Chun Li Yao-Qun |
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| Institution: | aDepartment of Chemistry, the Ministry of Education Key Laboratory of Analytical Sciences, Xiamen University, Xiamen 361005, China;bSchool of Physics and Mechanical & Electrical Engineering, Xiamen University, Xiamen 361005, China |
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| Abstract: | Wistar big mice were inoculated with sarcoma to simulate cancer in human.After extracting their serum with ethanol,the intensities of fluorescence band(630 nm) of supernatants was measured with first-order derivative fluorescence emission spectra.An obvious contrast between healthy and diseased serum could be observed,and diagnosis of malignant tumors at early stage could be achieved.There are no false negative sample in all the cancer samples,and there is only are sample that is fta false positive. |
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| Keywords: | Cancer protoporphyrin derivative fluorescence spectroscopy serum |
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