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| 马钱子与甘草配伍前后生物碱成分的变化规律 | |
| 引用本文： | 闫静,朱海光,刘志强,刘淑莹.马钱子与甘草配伍前后生物碱成分的变化规律[J].分析化学,2007,35(8):1218-1220. |
| 作者姓名： | 闫静 朱海光 刘志强 刘淑莹 |
| 作者单位： | 1. 中国科学院长春应用化学研究所,长春质谱中心,长春,130022;黑龙江中医药大学,哈尔滨,150040 2. 黑龙江中医药大学,哈尔滨,150040 3. 中国科学院长春应用化学研究所,长春质谱中心,长春,130022 |
| 基金项目： | 国家自然科学基金(No30472134,30672600)，国家科技部重大基础研究前期研究专项(No2003CCA03100)，中国科学院知识创新工程重要方向项目(NoKGCX2-SW-213-06)资助 |
| 摘 要： | 采用电喷雾质谱技术和高效液相色谱法分别对马钱子配伍甘草前后主要生物碱的变化规律进行了系统研究。实验结果表明,马钱子配伍甘草后其主要生物碱士的宁和马钱子碱的含量均有不同程度的降低,其中士的宁的含量下降显著。电喷雾质谱的实验结果与高效液相色谱的结果相吻合,为进一步阐明甘草解马钱子类药物毒性和马钱子合理配伍用药提供了科学的实验依据。 |
| 关 键 词： | 马钱子 生物碱 电喷雾质谱 高效液相色谱 |
| 修稿时间： | 2006-08-15 |
Studies on the Alkaloid Components in Strychnos Nux-vomical L.Uncombined and Combined with Glycyrrhiza Uralensis Fisch |
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| Yan Jing,Zhu Hai-Guang,Liu Zhi-Qiang,Liu Shu-Ying.Studies on the Alkaloid Components in Strychnos Nux-vomical L.Uncombined and Combined with Glycyrrhiza Uralensis Fisch[J].Chinese Journal of Analytical Chemistry,2007,35(8):1218-1220. | |
| Authors: | Yan Jing Zhu Hai-Guang Liu Zhi-Qiang Liu Shu-Ying |
| Institution: | Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun Center of Mass Spectrometry, Changchun 130022;Heilon~iang University of Traditional Chinese Medicine, Harbin 150040 |
| Abstract: | The alkaloid components in Strychnos nux-vomical L.uncombined and combined with Glycyrrhiza uralensis Fisch have been investigated by electrospray ionization tandem mass spectrometry(ESI-MSn) and HPLC.The experimental results demonstrated that the number of strychnine and brucine all declined in combined Strychnos nux-vomical L.with Glycyrrhiza uralensis Fisch,and the concentration level of strychnine fell obviously.The results of ESI-MS were identical to those of HPLC,which provided scientific basis for explanation of detoxicity of Glycyrrhiza uralensis Fisch and the reasonable combination of Strychnos nux-vomical L.. |
| Keywords: | Strychnos nux-vomical L alkaloid electrospray ionization mass spectrometry high performance liquid chromatography |
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