| 以_43~(99)Tc-二乙三胺五乙酸-白细胞介素三元体系对白细胞介素-2进行标记和检测 |
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| 引用本文： | 张玉萍,何锡文,朱守田,庞雁.以_43~(99)Tc-二乙三胺五乙酸-白细胞介素三元体系对白细胞介素-2进行标记和检测[J].分析化学,2000(12). |
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| 作者姓名： | 张玉萍 何锡文 朱守田 庞雁 |
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| 作者单位： | 南开大学化学系!天津300071(张玉萍，何锡文，朱守田)，天津肿瘤医院核医学研究室!天津300060(庞雁) |
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| 基金项目： | 南开大学元素有机化学国家重点开放实验室基金资助课题。 |
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| 摘 要： | 白细胞介素－２（ＩＬ－２）是机体免疫网络系统起重要调节作用的淋巴因子，它能激活多 种免疫细胞使其产生免疫活性。以９９４３Ｔｃ标记ＩＬ－２，用９９４３Ｔｃ－二乙三胺五乙酸（ＤＴＰＡ）－ＩＬ－２的三元 体系产物作为标记物进行检测，然后将标记物用于体内的ＩＬ－２受体显像的研究，有助于认识 某些疾病的发生机理，可用于监测某些疾病的动态变化和实验性治疗。
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| 关 键 词： | 白细胞介素-2 锝 放射性示踪 受体显像 |
Standardization and Determination of Interleakin-2 with _(43)~(99)Tc -Diethyltriaminepentaacetic Acid-Interleakin-2 System |
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| Zhang Yuping,He Xiwen.,Zhu Shoutian.Standardization and Determination of Interleakin-2 with _(43)~(99)Tc -Diethyltriaminepentaacetic Acid-Interleakin-2 System[J].Chinese Journal of Analytical Chemistry,2000(12). |
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| Authors: | Zhang Yuping He Xiwen Zhu Shoutian |
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| Abstract: | Interleakin-2 is very at important in immune system of human beings. It can activate variousimmune cells and make them exhibit immune activity. In this paper,we introduce a method of labeling the interleakin-2(IL2) with9943Tc. By using9943Tc to label IL-2, we have detected the product 9943Tcdiethyltriamine-pentaacetic acid (DTPA)-IL-2. Then, we use this labeled product in studying acceptor imaging in vivo. This method is helpful to study the mechanism of some diseases, and can be used both to detect kinetic change in certain illnesses and to therapy them experimentally. |
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| Keywords: | Interleakin-2 technetium radiotracer acceptor imag |
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