| 药物头孢氨苄分子模板聚合物水中结合性质的研究 |
| |
| 引用本文： | 郭洪声,何锡文.药物头孢氨苄分子模板聚合物水中结合性质的研究[J].分析化学,2000,28(10):1214-1219. |
| |
| 作者姓名： | 郭洪声 何锡文 |
| |
| 作者单位： | 南开大学化学系,天津,300071 |
| |
| 基金项目： | 国家自然科学基金!（No．29775011），天津市自然科学基金!（No．003602211）资助课题 |
| |
| 摘 要： | 采用分子模板技术合成了以头孢氨苄为模板分子以三氟甲基丙烯酸和４－乙烯基吡啶同时为功能单体的分子模板聚合物。将得到的棒状聚合物研磨过筛后，运用平衡结合实验研究了头孢氨苄分子模板聚合物的结合性质，Ｓｃａｔｃｈａｒｄ分析表明，在所研究的浓度范围内，在聚合物中形成了两类不同的结合位点。头孢氨苄分子模板聚合物与其化学组成相同的非模板聚合物相比，有很高的结合容量。底物选择性实验表明，与其它结构相似的药物相比，
|
| 关 键 词： | 分子印迹 头孢氨苄 分子识别 分子模板聚合物 |
A Study on the Binding Characteristics of Molecular Imprinted Polymer Selective for Cefalexin in Aqueous Media |
| |
| Guo Hongsheng,He Xiwen.A Study on the Binding Characteristics of Molecular Imprinted Polymer Selective for Cefalexin in Aqueous Media[J].Chinese Journal of Analytical Chemistry,2000,28(10):1214-1219. |
| |
| Authors: | Guo Hongsheng He Xiwen |
| |
| Institution: | Guo Hongsheng
,He Xiwen
(Department of Chemistry, Nankai University, Tianjin 300071) |
| |
| Abstract: | A kind of molecular imprinted polymer was prepared using cefalexin as the template molecule, both 2-(trifluoromethyl) acrylic acid and 4-vinylpyridine as functional monomer.The bulk polymer was ground up sieved and investigated in equilibrium binding experiment to evaluate the binding characteristic of the cefalexin-imprinted polymer. Scatchard analysis showed that two classes of binding sites were formed in the imprinted polymer under the studied concentration. The polymer gave much higher binding capacity for cefalexin than the non-imprinted polymer with the same chemical composition. The selectivity was evaluated by distribution coefficients of cefalexin and other compounds with similar structure. The results showed that the imprinted polymer exhibited high affinity for cefalexin among the tested compounds. |
| |
| Keywords: | Molecular imprinting cefalexin molecular recognition imprinted polymer |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
