| 稀土对大鼠代谢产物影响的核磁共振研究 |
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| 引用本文： | 李晓晶,冯江华,张善荣,裴奉奎,陈曦,聂毓秀.稀土对大鼠代谢产物影响的核磁共振研究[J].分析化学,2000,28(12):1472-1475. |
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| 作者姓名： | 李晓晶 冯江华 张善荣 裴奉奎 陈曦 聂毓秀 |
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| 作者单位： | 1. 中国科学院长春应用化学研究所,长春,130022
2. 白求恩医科大学,长春,130021 |
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| 基金项目： | 国家自然科学基金重大项目资助课题!（29890280）。 |
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| 摘 要： | 以高场核磁共振技术为研究手段，通过分析腹腔注射０．２、２、１０、２０ｍｇ／ｋｇ体重剂量的Ｌａ（ＮＯ３）３后大鼠尿液中代谢物浓度、物种的变化，研究了稀土化合物在动物体内的作用情况，结果表明，稀土的引入使动物肾脏和肝脏都受到一定程度的损伤，并在代谢物中挑选出了合适的ＮＭＲ ｍａｒｋｅｒｓ，其变化可以反映稀土离子作用后大鼠的异常代谢。
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| 关 键 词： | 稀土 体液 核磁共振 代谢 药理 毒理 |
Effect of Rare Earth Element on the Metabolism in Rats by High Resolution Proton Nuclear Magnetic Resonance Spectroscopy |
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| Li Xiaojing,Feng Jianghua,Zhang Shanrong,Pei Fengkui,Chen Xi,Nie Yuxiu.Effect of Rare Earth Element on the Metabolism in Rats by High Resolution Proton Nuclear Magnetic Resonance Spectroscopy[J].Chinese Journal of Analytical Chemistry,2000,28(12):1472-1475. |
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| Authors: | Li Xiaojing Feng Jianghua Zhang Shanrong Pei Fengkui Chen Xi Nie Yuxiu |
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| Abstract: | The high-field nuclear magnetic resonance (NMR) spectra can be used for the rapid multicomponent analysis in small amounts of biological fluids. In this paper, the effect of La(NO3 )3 on the rats metabolism in urine was investigated by 1H NMR analysis. The experimental groups of wistar rats were injected intraperitoneally with In(NO3)3 at doses of 0.2, 2.0, 10 and 20mg/kg body weight. The remarkable variation of low molecular weight metabolites in urine has been identified by 1H NMR spectra, in which dimethylamine, N, N-dimethylglycine, urea, a-ketoglutarate, trimethylamine N-oxide, succinate, citrate and amino acids have ho suggested as NMR markers for renal damage and ethanol, lactate, taurine as the markers for liver damage. This work may assess its possible use in the early detection of biochemical changes associated with Rare Earth induced kidney and liver dysfunction. |
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| Keywords: | Rare earth biofluids nuclear magnetic resonance metabolism |
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