| 咪喹莫特的波谱学数据与结构表征 |
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| 引用本文： | 夏广新,张容霞,索瑾,朱毅,沈敬山,嵇汝运.咪喹莫特的波谱学数据与结构表征[J].分析化学,2003,31(10):1183-1186. |
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| 作者姓名： | 夏广新 张容霞 索瑾 朱毅 沈敬山 嵇汝运 |
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| 作者单位： | 1. 中国科学院上海生命科学研究院药物研究所,上海,201203
2. 上海特化医药科技有限公司,上海,200031 |
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| 摘 要： | 对咪喹莫特的红外(IR)、紫外(UV)、质谱(MS)、氢-氢相关谱(^1H--^1H COSY)、碳氢相关谱(HMQC)、碳氢远程相关谱(HMBC)予以解析并进行了报道。对所有的^1H NMR、^13C NMR谱的信号进行了归属；讨论了质谱的主要碎片离子的可能的裂解方式和红外特征吸收峰所对应的官能团的振动形式。
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| 关 键 词： | 咪喹莫特 波谱学 数据 结构表征 核磁共振 质谱 红外 紫外 白细胞介素激动剂 药物 |
Spectral Data Analysis and Identification of Imiquimod |
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| Xia Guangxin ,Zhang Rongxia ,Suo Jin ,Zhu Yi ,Shen Jingshan ,Ji Ruyun.Spectral Data Analysis and Identification of Imiquimod[J].Chinese Journal of Analytical Chemistry,2003,31(10):1183-1186. |
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| Authors: | Xia Guangxin Zhang Rongxia Suo Jin Zhu Yi Shen Jingshan Ji Ruyun |
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| Institution: | Xia Guangxin 1,Zhang Rongxia 1,Suo Jin 1,Zhu Yi 2,Shen Jingshan *1,Ji Ruyun 1 1 |
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| Abstract: | The infrared spectrum, ultraviolet spectrum, mass spectrometry, 1H- 1H correlated spectroscopy ( 1H- 1H COSY), ( 1H detected)heteronuclear multiple-quantum coherence (HMQC), ( 1H detected)heteronuclear multiple bond coherence (HMBC) of Imiquimod were reported and interpreted. All the 1H nuclear magnetic resonance (NMR) and 13C NMR chemical shifts were assigned by means of 1H- 1H COSYHMQC and HMBC. The chemical structure of the main characteristic fragmentations and the vibrations of functional groups of this compound were discussed. |
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| Keywords: | Imiquimod nuclear magnetic resonance assignment mass spectrometry infrared spectrum ultraviolet spectrum |
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