| 高效液相色谱-串联质谱法鉴定伊维菌素的成分 |
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| 引用本文： | 雷荣,马丽娟,怀其勇,左育民.高效液相色谱-串联质谱法鉴定伊维菌素的成分[J].分析化学,2002,30(1):26-30. |
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| 作者姓名： | 雷荣 马丽娟 怀其勇 左育民 |
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| 作者单位： | 1. 天津南开大学化学系,天津,300071
2. 石家庄华晟生物化工厂,石家庄,050000 |
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| 摘 要： | 利用高效液相色谱从商品化伊维菌素中分离出8种组分，再与ESL－MS－MS偶合，得到其加合离子和特征子离子，从而对各组分的化学成分进行了鉴定，报道了伊维菌素B1a的^13C NMR谱图，并对碳信号作了归属。
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| 关 键 词： | 伊维菌素 阿维菌素 高效液相色谱 串联质谱 ^13C核磁共振谱 鉴定 兽药 化学成分 分析 |
Identification of Ivermectins by High Performance Liquid Chromatography-Electrospray-Mass Spectrometry-Mass Spectrometry |
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| Lei Rong,Ma Lijuan. Huai Qiyong Zuo Yumin.Identification of Ivermectins by High Performance Liquid Chromatography-Electrospray-Mass Spectrometry-Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2002,30(1):26-30. |
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| Authors: | Lei Rong Ma Lijuan Huai Qiyong Zuo Yumin |
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| Abstract: | fractions of commercial ivermectin were isolated and identified by high performance liquid chromatography-electrospray-mass spectrometry-mass spectrometry (HPLC-ESJ-MS-MS). The molecular ions themselves were not seen in the ESJ-MS spectra, but adduct ions such as NI + Na]* ions were prominent. The MSMS data of HPLC fractions were also obtained by the ESL-triple quadrapole mass spectrometer. The charaeteristic daughter ions could be used to distinguish the same molecular weight components. The 13C nuclear magnetic resonance (NMR) spectrum of ivermectin B1, was reported and explained with its structure. |
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| Keywords: | Ivermectin avermectin high performance liquid chromatography mass spectrometry-mass spectrometry 13C nuclear magnetic resonance |
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