| 基于冠心病心肌缺血血瘀证小型猪血清核磁共振代谢组学的研究 |
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| 引用本文： | 王勇,李中峰,陈建新,啜文静,李春,郭淑贞,赵慧辉,王伟,王英锋.基于冠心病心肌缺血血瘀证小型猪血清核磁共振代谢组学的研究[J].分析化学,2011,39(8):1274-1278. |
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| 作者姓名： | 王勇 李中峰 陈建新 啜文静 李春 郭淑贞 赵慧辉 王伟 王英锋 |
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| 作者单位： | 1. 北京中医药大学药理教研室,北京,100029
2. 首都师范大学化学系,北京,100037 |
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| 基金项目： | 国家科技重大专项(No.2009ZX09502-018); 国家自然科学基金(No.30902020)资助 |
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| 摘 要： | 通过左冠状动脉前降支放置Ameriod环制备冠心病慢性心肌缺血动物模型,并结合冠脉造影等方法确立中医血瘀证证候,采用现代核磁共振(NMR)和模式识别技术,分析冠心病心肌缺血血瘀证模型与假手术组小型猪4星期血清的共振氢谱,及相应代谢物谱群的变化,开展中医血瘀证候学的研究.结果显示,该方法制备的模型4星期后确立为稳定的冠心...
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| 关 键 词： | 冠心病 血瘀证 核磁共振 代谢组学 |
Study of Mini-pig Serum of Coronary Heart Disease(Chronic Myocardial Ischemia) with Syndrome of Blood Stasis Based on Nuclear Magnetic Resonance Metabolomics |
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| WANG Yong,LI Zhong-Feng,CHEN Jian-Xin,CHUO Wen-Jing,LI Chun,GUO Shu-Zhen,ZHAO Hui-Hui,WANG Wei,WANG Ying-Feng.Study of Mini-pig Serum of Coronary Heart Disease(Chronic Myocardial Ischemia) with Syndrome of Blood Stasis Based on Nuclear Magnetic Resonance Metabolomics[J].Chinese Journal of Analytical Chemistry,2011,39(8):1274-1278. |
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| Authors: | WANG Yong LI Zhong-Feng CHEN Jian-Xin CHUO Wen-Jing LI Chun GUO Shu-Zhen ZHAO Hui-Hui WANG Wei WANG Ying-Feng |
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| Institution: | WANG Yong1,LI Zhong-Feng 2,CHEN Jian-Xin 1,CHUO Wen-Jing 1,LI Chun 1,GUO Shu-Zhen 1,ZHAO Hui-Hui1,WANG Wei 1*,WANG Ying-Feng 2 1(Department of Pharmacology of Traditional Chinese Medicine,Beijing University of Chinese Medicine,Beijing 100029) 2(Capital Normal University,Beijing 100037) |
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| Abstract: | To study coronary heart disease(chronic myocardial ischemia) with syndrome of blood stasis caused by Ameriod ring and its changes in the serum metabolite profiling,coronary angiography is used to evaluate the syndrome of the model,and nuclear magnetic resonance(NMR) and pattern recognition to analyze hydrogen resonance spectra of myocardial ischemia in coronary heart disease with syndrome of blood stasis after operated for 4 weeks.The results show that the principal component analysis(PCA) of serum NMR spec... |
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| Keywords: | Coronary heart disease Syndrome of Chinese Medicine Nuclear magnetic resonance Metabolomics |
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