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| 气相色谱-质谱法检测人血清样品中新型含氯阻燃剂德克隆 | |
| 引用本文： | 任国发,罗湘凡,马盛韬,孙延枫,于志强,盛国英,傅家谟.气相色谱-质谱法检测人血清样品中新型含氯阻燃剂德克隆[J].分析化学,2011,39(2):235-238. |
| 作者姓名： | 任国发 罗湘凡 马盛韬 孙延枫 于志强 盛国英 傅家谟 |
| 作者单位： | 1. 中国科学院广州地球化学研究所有机地球化学国家重点实验室,广东省环境资源利用与保护重点实验室,广州510640;上海大学环境与化学工程学院环境污染与健康研究所,上海200444 2. 上海大学环境与化学工程学院环境污染与健康研究所,上海,200444 3. 中国科学院广州地球化学研究所有机地球化学国家重点实验室,广东省环境资源利用与保护重点实验室,广州510640 |
| 基金项目： | 国家973计划(No.2008CB418205); 有机地球化学国家重点实验室项目(No.OGL-200901)资助 |
| 摘 要： | 采用液液萃取,气相色谱-负离子化学电离质谱技术,建立了人体血清样品中新型含氯阻燃剂德克隆(DP)的分离分析方法.血清样品蛋白质变性后,采用液液萃取法提取脂肪,再采用浓H2SO4破坏法去除大部分脂肪,最后采用酸性硅胶柱进一步净化.净化后的样品经浓缩富集,采用气相色谱-负离子化学电离质谱仪测定样品中DP两种同分异构体的含量... |
| 关 键 词： | 德克隆 新型有机污染物 气相色谱 负离子化学源 血清 |
Quantification of Dechlorane Plus in Human Serum by Gas Chromatography Coupled with Negative Chemical Ionization Mass Spectrometry |
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| REN Guo-Fa,LUO Xiang-Fan,MA Sheng-Tao,SUN Yan-Feng,YU Zhi-Qiang,SHENG Guo-Ying,FU Jia-Mo.Quantification of Dechlorane Plus in Human Serum by Gas Chromatography Coupled with Negative Chemical Ionization Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2011,39(2):235-238. | |
| Authors: | REN Guo-Fa LUO Xiang-Fan MA Sheng-Tao SUN Yan-Feng YU Zhi-Qiang SHENG Guo-Ying FU Jia-Mo |
| Institution: | REN Guo-Fa*1,2,LUO Xiang-Fan2,MA Sheng-Tao1,SUN Yan-Feng2,YU Zhi-Qiang*1,SHENG Guo-Ying1,FU Jia-Mo1,2 1(State Key Laboratory of Organic Geochemistry,Guangdong Key Laboratory of Environment and Resources,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences,Guangzhou 510640) 2(Institute of Environmental Pollution and Health,School of Environment and Chemical Engineering,Shanghai University,Shanghai 200444) |
| Abstract: | A gas chromatography coupled with negative chemical ionization mass spectrometric(GC-NCI-MS) method was developed for the determination of two dechlorane plus(DP) isomers in human serum sample.Target compound and serum lipid were extracted by lipid-lipid extraction.After the sulfuric acid treatment to remove extracted lipids from the samples,samples were further cleaned up with a silica/sulfuric acid column.Identification and quantification of DP were carried out by MS.The detection limit of instrument was ... |
| Keywords: | Dechlorane plus Emerging contaminant Gas chromatography Negative chemical ionization Human serum |
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