| 手性高效液相色谱法测定1—（6‘—甲氧基萘）乙醇不对称氢酯基化反应 |
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| 引用本文： | 侯经国,王亚丽.手性高效液相色谱法测定1—（6‘—甲氧基萘）乙醇不对称氢酯基化反应[J].分析化学,1998,26(3):298-302. |
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| 作者姓名： | 侯经国 王亚丽 |
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| 作者单位： | [1]中国科学院兰州化学物理研究所 [2]西北师范大学化学化工学院 |
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| 基金项目： | 中国科学院重点基金资助项目 |
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| 摘 要： | 在自制的硅基纤维素－三（３，５－二甲基苯基氨基甲酸酯）高效液相色谱手性固定相上（ＨＰＬＣ－ＣＳＰ），优化了１－（６＇－甲氧基萘）乙醇氢酯基化反应产物－萘普生甲酯手性分离的条件，测定了相应的一系列不对称氢酯基化反应产物的对映体过剩值（ｅ．ｅ．值）。结果表明，在ＣＤＭＰＣ－ＣＳＰ手性柱上用ＨＰＬＣ测定此类不对称催化反应的光学产率，评价催化剂体系的手性选择是一种非常理想的方法。
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| 关 键 词： | HPLC 不对称 CSP 甲氧基萘 CDMPC 乙醇 氢酯基化 |
Determination of Enantiomer Excess Value for the Asymmetric Hydroesterification Reaction of 1-(6'-Methoxylnaphthyl)ethanol Using Chiral High PerformanceLiquid Chromatographic Method |
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| Hou Jingguo,Zhou Hongying,Zhou Zhiqiang,Chen Liren,Ou Qingyu.Determination of Enantiomer Excess Value for the Asymmetric Hydroesterification Reaction of 1-(6''''-Methoxylnaphthyl)ethanol Using Chiral High PerformanceLiquid Chromatographic Method[J].Chinese Journal of Analytical Chemistry,1998,26(3):298-302. |
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| Authors: | Hou Jingguo Zhou Hongying Zhou Zhiqiang Chen Liren Ou Qingyu |
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| Abstract: | The chiral separation of the racemic naphthxen methyl ester on the cellulose tris (3,5-dimethylphenylcarbamate)chiral stationary phase prepared by us has been investigated. Under optimum conditions, the enantiomer excess value of the product, naphthxen methyl ester and asymmetric hydroestrification reaction is determined by HPLC with a direct injecting way after samples are diluted with the mobile phase. The results show that the method established is very ideal for evaluating the enantioselectivity of asymmetric catalytic reactions. |
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| Keywords: | High performance liquid chromatography chiral stationary phase cellulose tries (3 5-dimethylphenylcarbamate) enantiomer |
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