| 多壁碳纳米管修饰铂基片石英晶体微天平研究白细胞介素-6与其受体的相互作用 |
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| 引用本文： | 房钰鑫,商洪才,秦霞,樊官伟,张迪,赵薇,李争春,张伯礼,陈强.多壁碳纳米管修饰铂基片石英晶体微天平研究白细胞介素-6与其受体的相互作用[J].分析化学,2011(9):1302-1306. |
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| 作者姓名： | 房钰鑫 商洪才 秦霞 樊官伟 张迪 赵薇 李争春 张伯礼 陈强 |
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| 作者单位： | 南开大学生命科学学院生物活性材料教育部重点实验室;天津中医药大学中医药研究院; |
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| 基金项目： | 国家自然科学基金(Nos.30870665,30772746,90709038); 天津市自然科学基金(Nos.08JCZDJC20600,09ZCGHHZ00100)资助项目 |
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| 摘 要： | 在pH 7.4、室温条件下,用多壁碳纳米管(MWCNTs)修饰石英晶体微天平(QCM) Pt基片,经过EDC/NHS活化后固定白细胞介素-6(IL-6),检测不同浓度可溶性白细胞介素-6受体(sIL-6R)与IL-6的结合所引起响应信号的变化,并用Origin软件对数据进行拟合分析,构建了一种高性能实时监测IL-6与s...
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| 关 键 词： | 多壁碳纳米管 Pt基片 石英晶体微天平 白细胞介素-6 可溶性白细胞介素-6受体 |
Interaction of Interleukin-6 and Soluble Interleukin-6 Receptor Based on Multi-walled Carbon Nanotubes Activated Pt Quartz Crystal Microbalance |
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| FANG Yu-Xin,SHANG Hong-Cai,QIN Xia,FAN Guan-Wei,ZHANG Di,ZHAO Wei,LI Zheng-Chun,ZHANG Bo-Li,CHEN Qiang.Interaction of Interleukin-6 and Soluble Interleukin-6 Receptor Based on Multi-walled Carbon Nanotubes Activated Pt Quartz Crystal Microbalance[J].Chinese Journal of Analytical Chemistry,2011(9):1302-1306. |
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| Authors: | FANG Yu-Xin SHANG Hong-Cai QIN Xia FAN Guan-Wei ZHANG Di ZHAO Wei LI Zheng-Chun ZHANG Bo-Li CHEN Qiang |
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| Institution: | FANG Yu-Xin1,SHANG Hong-Cai2,QIN Xia1,FAN Guan-Wei2,ZHANG Di1,ZHAO Wei1,LI Zheng-Chun1,ZHANG Bo-Li2,CHEN Qiang2 1(The Key Laboratory of Bioactive Materials,Ministry of Education,College of Life Science,Nankai University,Tianjin 300071) 2(Institute of Traditional Chinese Medicine Research,Tianjin University of Traditional Chinese Medicine,Tianjin 300193) |
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| Abstract: | An affinity biosensor using multi-walled carbon nanotubes to activate Pt quartz crystal microbalance(QCM) electrode and immobilizing interleukin-6(IL-6) on 1-ethyl-3-(3-dimethylaminopropyl) carbodimide(EDC)/N-hydroxysuccinimide(NHS)-activated QCM electrode was employed to real time detect the interaction and kinetic analysis of IL-6 and soluble interleukin-6 receptor(sIL-6R),and the association data between IL-6 and sIL-6R was fitted by Origin software.The results showed that the combined masses of sIL-6R o... |
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| Keywords: | Multi-walled carbon nanotubes Platinum electrode Quartz crystal microbalance Interleukin-6 Soluble interleukin-6 receptor |
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