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| 高效液相色谱技术在代谢组学研究中的应用 | |
| 引用本文： | 谢跃生,潘桂湘,高秀梅,刘昌孝.高效液相色谱技术在代谢组学研究中的应用[J].分析化学,2006,34(11):1644-1648. |
| 作者姓名： | 谢跃生 潘桂湘 高秀梅 刘昌孝 |
| 作者单位： | 1. 天津药物研究院,天津药代动力学与药效动力学省部共建国家重点实验室,天津,300193;沈阳药科大学药代实验室,沈阳,110016 2. 天津中医药大学中医药研究所,天津,300193 3. 天津药物研究院,天津药代动力学与药效动力学省部共建国家重点实验室,天津,300193 |
| 基金项目： | 国家973计划资助项目(No.2005CB523404)，天津市科技发展计划项目(No.05YFZJC01102) |
| 摘 要： | 高效液相色谱技术逐渐广泛应用于代谢组学的研究中。迄今为止,该技术已经在不同生理状态的生物体液的代谢指纹谱分析中得到了应用。本文评述了传统高效液相色谱技术、毛细管技术和超高效液相色谱等技术在代谢组学的应用。 |
| 关 键 词： | 高效液相色谱 代谢组学 生物标志物 评述 |
| 收稿时间： | 02 22 2006 12:00AM |
| 修稿时间： | 2006-02-222006-05-27 |
Application of High Performance Liquid Chromatographic Technique in Metabonomics Studies |
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| Xie Yuesheng,Pan Guixiang,Gao Xiumei,Liu Changxiao.Application of High Performance Liquid Chromatographic Technique in Metabonomics Studies[J].Chinese Journal of Analytical Chemistry,2006,34(11):1644-1648. | |
| Authors: | Xie Yuesheng Pan Guixiang Gao Xiumei Liu Changxiao |
| Institution: | 1,Tianjin State Key Laboratory of Pharmacokinetics and Pharmacodynamics, Tianjin Institute of Pharmaceutical Research, Tianjin 300193 ;2,Pharmacokinetics Laboratory of Shenyang Pharmaceutical University, Shenyang 110016;3, Institute of Traditional Medicines, Tianjin University of Traditional Chinese Medicine, Tianjin 300193 |
| Abstract: | High performance liquid chromatographic(HPLC) technique has been employed in metabonomics studies recently.To date the technique has been applied to the analysis of bio-fluid obtained from studies in rodents in investigations of physiological variation and toxicity.In this review,the developments of application of conventional high performance liquid chromatography,capillary methods,ultra performance liquid chromatography are described. |
| Keywords: | High performance liquid chromatography metabonomics biomarker review |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |