| 固相萃取-高效液相色谱法测定人体尿液中邻苯二甲酸酯及其代谢物 |
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| 引用本文： | 林兴桃,王小逸,夏定国,吴琼,赵靖强.固相萃取-高效液相色谱法测定人体尿液中邻苯二甲酸酯及其代谢物[J].分析化学,2011,39(6):877-881. |
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| 作者姓名： | 林兴桃 王小逸 夏定国 吴琼 赵靖强 |
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| 作者单位： | 林兴桃,王小逸,吴琼,赵靖强,LIN Xing-Tao,WANG Xiao-Yi,WU Qiong,ZHAO Jing-Qiang(北京工业大学环境与能源工程学院,北京,100124);夏定国,XIA Ding-Guo(北京大学工学院,北京,100871) |
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| 基金项目： | 北京市教委科技发展计划基金，北京工业大学青年科研基金 |
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| 摘 要： | 建立了同时测定人体尿液中邻苯二甲酸酯及其代谢物的分析方法.对洗脱剂种类、洗脱体积、洗脱流速等影响因素进行考察,确定了最佳洗脱剂及洗脱体积为2mL乙腈、2mL乙酸乙酯和1mL乙醚-正己烷(1:19,V/V),洗脱流速1mL/min.在最优化的固相萃取-液相色谱条件下测定5种邻苯二甲酸酯及其5种相应的单酯代谢物,线性范围为...
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| 关 键 词： | 固相萃取 液相色谱 邻苯二甲酸酯 代谢物 尿液 |
Determination of Phthalic Acid Esters and Their Metabolites in Human Urine by Solid Phase Extraction-High Performance Liquid Chromatography |
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| LIN Xing-Tao,WANG Xiao-Yi,XIA Ding-Guo,WU Qiong,ZHAO Jing-Qiang.Determination of Phthalic Acid Esters and Their Metabolites in Human Urine by Solid Phase Extraction-High Performance Liquid Chromatography[J].Chinese Journal of Analytical Chemistry,2011,39(6):877-881. |
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| Authors: | LIN Xing-Tao WANG Xiao-Yi XIA Ding-Guo WU Qiong ZHAO Jing-Qiang |
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| Institution: | LIN Xing-Tao1,WANG Xiao-Yi1,XIA Ding-Guo2,WU Qiong1,ZHAO Jing-Qiang1 1(College of Environmental and Energy Engineering,Beijing University of Technology,Beijing 100124) 2(College of Engineering,Peking University,Beijing 100871) |
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| Abstract: | A solid phase extraction-high performance liquid chromatographic(SPE-HPLC) method was developed for the determination of phthalic acid esters and their metabolites in human urine.The conditions of pretreatment such as eluent,elution volume and elution velocity were optimized.The optimized conditions were 2 mL of acetonitrile,2 mL of ethyl acetate and 1 mL of ethyl ester-n-hexane(1/19,V/V) at the flow rate of 1 mL/min.Under the optimized conditions,five phthalic acid esters and their monoesters were determin... |
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| Keywords: | Solid phase extraction Liquid chromatography Phthalic acid esters Metabolites Urine |
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