| 喹诺酮类药物对人血清白蛋白的荧光猝灭研究 |
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| 引用本文： | 徐岩,沈含熙.喹诺酮类药物对人血清白蛋白的荧光猝灭研究[J].分析化学,1998,26(12):1494-1497. |
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| 作者姓名： | 徐岩 沈含熙 |
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| 作者单位： | [1]河北理工学院化工系 [2]南开大学化学系 |
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| 摘 要： | 观察了喹诺酮药物萘啶酸及氟哌酸对人血清白蛋白荧光的猝灭现象。根据药物对天然白蛋白及变性白蛋白荧光猝灭的不同表现,研究了萘啶酸和氟哌酸对人血清白蛋白荧光的猝灭机理,并探讨了药物与血清白蛋白的结合情况。
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| 关 键 词： | 萘啶酸 氟哌酸 人血清白蛋白 荧光猝灭 喹诺酮 |
Fluorescence Quenching Behavior of Human Serum Albumin by Quinolone Antibacterials |
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| Xu Yan, Huang Hanguo.Fluorescence Quenching Behavior of Human Serum Albumin by Quinolone Antibacterials[J].Chinese Journal of Analytical Chemistry,1998,26(12):1494-1497. |
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| Authors: | Xu Yan Huang Hanguo |
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| Abstract: | The fluorescence quenching behavior of human serum albumin by the quinolone antibacterials, nalidixic acid and norfloxacin, has been studied in detail. The "inner filtering effect"originatal form the absorption of the drug molecules was cometed by the Steiner method. The fluorescence quenching mechanism of human serum albumin(HSA) by medicines and the difference of binding of nalidixic acid and norfloxacin to HSA was discussed. |
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| Keywords: | Human serum albumin fluorescence quenching nalidixic acid norfloxacin |
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