| 芦荟大黄素与血清白蛋白的相互作用 |
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| 引用本文： | 王敬政,贺吉香,江崇球.芦荟大黄素与血清白蛋白的相互作用[J].分析化学,2001,29(7):782-784. |
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| 作者姓名： | 王敬政 贺吉香 江崇球 |
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| 作者单位： | 山东师范大学化学系, |
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| 基金项目： | 山东自然科学基金资助项目 |
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| 摘 要： | 利用荧光光度法研究了中药有效成分芦荟大黄素与血清白蛋白的相互作用机制 ,求得两者的形成常数 ,讨论了某些金属离子对其形成常数的影响 ,并根据热力学常数确定了它们之间的作用力类型 ,利用F rster非辐射能量转移技术求出了两者的结合位置。
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| 关 键 词： | 芦荟大黄素 血清白蛋白 荧光猝灭法 |
| 修稿时间： | 2000年8月10日 |
The Interaction of Serum Albumin with Aloe-emodin |
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| Wang Jingzheng,He Jixiang,Jiang Chongqiu.The Interaction of Serum Albumin with Aloe-emodin[J].Chinese Journal of Analytical Chemistry,2001,29(7):782-784. |
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| Authors: | Wang Jingzheng He Jixiang Jiang Chongqiu |
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| Institution: | Wang Jingzheng,He Jixiang,Jiang Chongqiu * |
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| Abstract: | In this paper, we have studied the interaction of serum albumin (BSA and HSA) with Aloe emodin by fluorescence quenching method. The binding constants were obtained at different temperatures. We have also discussed the binding constants in the presence of various metal ions. According to the thermodynamic parameters, the main sorts of binding force have been obtained. The results showed that. the mechanism of quenching belonged to static quenching and the main sorts of binding force are static electricity gravitation and Van der Waals force. |
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| Keywords: | Aloe emodin serum albumin fluorescence quenching method |
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