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固相萃取-同位素稀释-气相色谱-串联质谱法测定化妆品中的二甲苯麝香
引用本文:马强,白桦,王超,马微,张庆,肖海清,周新,董益阳,王宝麟.固相萃取-同位素稀释-气相色谱-串联质谱法测定化妆品中的二甲苯麝香[J].分析化学,2009,37(12).
作者姓名:马强  白桦  王超  马微  张庆  肖海清  周新  董益阳  王宝麟
作者单位:1. 中国检验检疫科学研究院,北京,100123
2. 黑龙江出入境检验检疫局,哈尔滨,150086
基金项目:中国检验检疫科学研究院基本科研业务费专项基金 
摘    要:建立了测定化妆品中二甲苯麝香的固相萃取-同位素稀释-气相色谱-串联质谱分析方法.膏霜、水剂、散粉、香波、唇膏等不同类型的化妆品样品加入甲醇经超声提取后,样品提取液高速离心处理,浓缩上清液,以Sep-Pak Silica固相萃取柱净化,收集二氯甲烷洗脱液,DB-5 MS(30 m × 0.25 mm, 0.25 μm)石英毛细管色谱柱分离后经NCI-GC-MS/MS多反应监测技术进行定性及定量分析.二甲苯麝香的方法定量限为5 μg/kg,在5~50 μg/kg范围内的3个添加水平的平均回收率为81.1%~86.9%,日内精密度均小于10%,日间精密度均小于12%.本方法准确、快速、灵敏度高,可用于化妆品的实际检验工作.

关 键 词:固相萃取  同位素稀释  气相色谱-串联质谱  化妆品  二甲苯麝香

Determination of Musk Xylene in Cosmetics by Solid Phase Extraction-Isotope Dilution-Gas Chromatography Tandem Mass Spectrometry
MA Qiang,BAI Hua,WANG Chao,MA Wei,ZHANG Qing,XIAO Hai-Qing,ZHOU Xin,DONG Yi-Yang,WANG Bao-Lin.Determination of Musk Xylene in Cosmetics by Solid Phase Extraction-Isotope Dilution-Gas Chromatography Tandem Mass Spectrometry[J].Chinese Journal of Analytical Chemistry,2009,37(12).
Authors:MA Qiang  BAI Hua  WANG Chao  MA Wei  ZHANG Qing  XIAO Hai-Qing  ZHOU Xin  DONG Yi-Yang  WANG Bao-Lin
Institution:MA Qiang1,BAI Hua1,WANG Chao1,MA Wei2,ZHANG Qing1,XIAO Hai-Qing1,ZHOU Xin1,DONG Yi-Yang1,WANG Bao-Lin1 1(Chinese Academy of Inspection and Quarantine,Beijing 100123) 2(Heilongjiang Entry-Exit Inspection and Quarantine bureau.Harbin 150086)
Abstract:A comprehensive analytical method based on solid phase extraction-isotope dilution-gas chromatography tandem mass spectrometry has been developed for the determination of musk xylene in cosmetics.Various cosmetic samples,including cream,lotion,powder,shampoo and lipstick,were extracted under ultrasonication.The extract was centrifuged,and the upper solution was concentrated by rotary evaporator.The reconstructed solution was then cleaned up by Sep-Pak Silica solid phase extraction cartridge.Qualitative and ...
Keywords:Solid phase extraction  isotope dilution  gas chromatography tandem mass spectrometry  cosmetics  musk xylene
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