双源CT双能量参数联合血清miR-126、miR-204检测对肺癌诊断价值及与临床病理特征关联性

回顾性选取肺癌患者86例为肺癌组,同期肺良性结节患者86例为对照组,患者均行双源CT双能量、血清miR-126、miR-204水平检测,发现静脉期标准化碘浓度(NIC)、动脉期NIC、miR-204、miR-126水平在肺癌组中呈异常表达,并与肺癌组病理类型、临床分期、淋巴结转移存在一定相关性,三者联合对肺癌具有一定诊断价值。同时经Kaplan-Meier生存分析可知,肺癌组静脉期NIC、动脉期NIC高水平患者生存率低于低水平患者,而miR-126、miR-204高水平患者生存率高于低水平患者(P<0.05)。早期采用双源CT双能量、血清miR-126、miR-204联合诊断,可为临床诊治、预后评估提供循证指导。

The Diagnostic Value of Dual-source CT Dual-energy Parameters Combined with Serum miR-126 and miR-204 Detection in Lung Cancer and Its Correlation with Clinicopathological Characteristics

A total of 86 patients with lung cancer were retrospectively selected as the lung cancer group,and 86 patients with benign pulmonary nodules as the control group during the same period.Dual-source CT dual energy,serum miR-126,miR-204 levels were detected in all patients.It was found that the normalized iodine concentration(NIC)in the venous phase,NIC in the arterial phase,serum miR-204,miR-126 levels were abnormally expressed in the lung cancer group,and there was a certain correlation with the pathological type,clinical stage,and lymph node metastasis of the lung cancer group.The combination of the three had certain diagnostic value for lung cancer.At the same time,Kaplan-Meier survival analysis showed that the survival rate of patients with high levels of NIC in the venous phase and arterial phase in the lung cancer group was lower than that of patients with low levels.The survival rates of patients with high levels of serum miR-126 and miR-204 were higher than those with low levels(P<0.05).It can be seen that the early combined diagnosis of dual-source CT dual-energy,serum miR-126,and miR-204 can provide evidence-based guidance for clinical diagnosis and treatment and prognosis evaluation.