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硅纳米线阵列电极作为细胞色素c传感器的研究
引用本文:杨坤,陈欢,赵文超,王建涛,王辉,张晓宏.硅纳米线阵列电极作为细胞色素c传感器的研究[J].影像科学与光化学,2009,27(2):87-94.
作者姓名:杨坤  陈欢  赵文超  王建涛  王辉  张晓宏
作者单位:1. 中国科学院,理化技术研究所,纳米有机光电子实验室,北京,100190;中国科学院,研究生院,北京,100039
2. 中国科学院,理化技术研究所,纳米有机光电子实验室,北京,100190
基金项目:国家重点基础研究发展规划(973计划),国家高技术研究发展计划(863计划) 
摘    要:利用化学刻蚀法由p型硅片制备了硅纳米线阵列,经过表面去氧化层处理后,制备了检测蛋白质细胞色素c的电化学传感器.实验表明,硅纳米线阵列电极对细胞色素c有良好的电化学响应,并且在低浓度条件下具备线性响应的特点.根据与未经表面处理的硅纳米线阵列电极的实验结果相对比,提出了细胞色素c所具备的羧基末端与硅纳米线阵列电极表面的Si-H相互作用从而改善传感性能的检测机理.

关 键 词:硅纳米线阵列  电化学传感器  细胞色素c

Silicon Nanowire Arrays as Electrochemical Biosensors for Cytochrome c
YANG Kun,CHEN Huan,ZHAO Wen-chao,WANG Jian-tao,WANG Hui,ZHANG Xiao-hong.Silicon Nanowire Arrays as Electrochemical Biosensors for Cytochrome c[J].Imaging Science and Photochemistry,2009,27(2):87-94.
Authors:YANG Kun  CHEN Huan  ZHAO Wen-chao  WANG Jian-tao  WANG Hui  ZHANG Xiao-hong
Abstract:The direct electrochemical biosensor for cytochrome c based on the silicon nanowire arrays was fabricated.The silicon nanowire arrays were prepared from the etched silicon wafer,which were then treated with aqua regia and HF to remove the cladding silicon oxide sheath.The modified silicon nanowire arrays were further used as the electrode for fabricating the direct electrochemical biosensors for the detection of cytochrome c,which exhibited linear response to cytochrome c at low concentration and high sensitivity of 2.75 μA·mmol-1·L due to the vast surface-to-bulk ratio of the silicon nanowire arrays and the interaction between the carboxyl group of cytochrome and Si-H group provided by the surface of the modified silicon nanowire arrays.
Keywords:silicon nanowire arrays  electrochemical biosensors  cytochrome c
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