| 磺化酞菁类染料光敏氧化胆固醇及L-半胱氨酸的反应 |
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| 引用本文： | 宋金华,安静仪,许慧君.磺化酞菁类染料光敏氧化胆固醇及L-半胱氨酸的反应[J].影像科学与光化学,1991,9(1):36-43. |
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| 作者姓名： | 宋金华 安静仪 许慧君 |
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| 作者单位： | 中国科学院感光化学研究所, 北京 100101 |
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| 摘 要： | 本文合成了磺化酞菁、磺化酞菁镓和磺化酞菁铝,研究了它们光敏氧化胆固醇及L-半胱氨酸的反应。染料的聚集态和溶液的pH值对反应速率有不同程度的影响。D2O加速反应而NaN3猝灭反应的结果表明,光敏氧化反应主要通过Ⅱ型(涉及1O2)机制进行。
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| 关 键 词： | 酞菁 光敏氧化 L-半胱氨酸 胆固醇 光动态效应 肿瘤 |
| 收稿时间： | 1989-05-05 |
SENSITIZED PHOTOOXIDIZATION OF CHOLESTEROL AND L-CYSTEINE BY PHTHALOCYANINE SULFONATES |
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| SONG JIN-HUA,AN JIN-YI,XU HUI-JUN.SENSITIZED PHOTOOXIDIZATION OF CHOLESTEROL AND L-CYSTEINE BY PHTHALOCYANINE SULFONATES[J].Imaging Science and Photochemistry,1991,9(1):36-43. |
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| Authors: | SONG JIN-HUA AN JIN-YI XU HUI-JUN |
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| Institution: | Institute of Photographic Chemistry, Academia Sinica, Beijing 100101, P.R. China |
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| Abstract: | Phthalocyanine sulfonates (H2SPC). chlorogallium phthalocyanine (CaClSPC) and chlor-oaluminum phthalocyanine (A1C1SPC) have been synthesized and their sensitized photooxid-ation of cholesterol and L-cysteine have been studied. Both aggregation of dyes and pH value of the solution affect the reaction rate. The results of enhancement of photooxidation rate observed when D2O was used as the solvent and the quenching effect of NaN2 indicate that sensitized photooxidation proceeds mainly via Type Ⅱ mechanism (involving singlet oxygen 2O2). |
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| Keywords: | Phthalocyanine sensitized photooxidization cholesterol L-cysteine photo-dynamic therapy |
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