螺旋CT成像联合血清copeptin、IL-18水平检测在急性脑梗死患者神经功能及预后评估中的应用价值

本文选取74例急性脑梗死(ACI)患者作为研究对象,入院时根据美国国立卫生院卒中量表(NIHSS)评分分为重度组(NIHSS评分>15分,n=21)、中度组(NIHSS评分5~15分,n=24)、轻度组(NIHSS评分<5分,n=29),均接受血清copeptin和IL-18水平检测及螺旋CT成像检查。结果发现,随ACI神经功能缺损加重,血清copeptin、白细胞介素18(IL-18)水平及峰值时间升高,CBV、CBF异常下降。经ROC曲线显示,血清IL-18联合CBF预测ACI患者预后不良的曲线下面积(AUC)最大。由上述结果可见螺旋CT成像参数、血清copeptin、IL-18水平与ACI患者神经功能存在一定相关性,三者联合为临床实现ACI患者个体化治疗和改善预后提供了可能。

Application Value of Spiral CT Imaging Combined with Detection of Serum Copeptin and IL-18 Levels in Neurological Function and Prognosis Assessment of Patients with Acute Cerebral Infarction

A total of 74 patients with ACI in our hospital were selected as the research objects.According to the National Institutes of Health Stroke Scale(NIHSS)score,they were divided into severe group(NIHSS score>15 points,n=21),moderate group(NIHSS score 5-15 points,n=24),and mild group(NIHSS score<5 points,n=29).All received the detection of serum copeptin,IL-18 levels and spiral CT imaging.The results showed that with the aggravation of ACI neurological deficits,serum copeptin and interleukin 18(IL-18)levels and peak time increased,while CBV and CBF decreased abnormally.The ROC curve showed that the area under the curve(AUC)of serum IL-18 combined with CBF to predict poor prognosis of ACI patients was the largest.It can be seen that there is a certain correlation between spiral CT imaging parameters,serum copeptin,IL-18 and the neurological function of ACI patients.The combination of the three provides the possibility to achieve individualized treatment of ACI patients and improve the prognosis.