| 交联壳聚糖树脂对部分尿毒症毒物的吸附性能研究 |
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| 引用本文： | 王虹,张明明,袁直,滕欣莲,何炳林.交联壳聚糖树脂对部分尿毒症毒物的吸附性能研究[J].离子交换与吸附,2002,18(3):193-198. |
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| 作者姓名： | 王虹 张明明 袁直 滕欣莲 何炳林 |
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| 作者单位： | 1. 吸附分离功能高分子材料国家重点实验室,南开大学高分子化学研究所,天津,300071
2. 南开大学化学系,天津,300071 |
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| 基金项目： | 教育部骨干教师基金，教育部重点科技项目 (98098)，博士点基金 (98005503) |
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| 摘 要： | 用反向悬浮的方法制备了戊二醛交联壳聚糖树脂吸附剂,并对制得的球形吸附剂用NaBH4进行了氢化还原处理,以提高其在使用环境下的化学稳定性。扫描电子显微镜(SEM)分析表明,吸附剂的表面形态构成了吸附的微观基础。通过对部分尿毒症毒性物质的吸附研究发现,本文研制的壳聚糖吸附剂对这些目标物均产生了一定的吸附作用,吸附平衡时间符合临床要求,其对3种小分子尿毒症毒性物质的吸附能力依肌酐、尿酸、尿素的次序递增,而对促皮质素(ACTH)的吸附量则达到了13.04mg/g,显示了该类吸附剂应用于临床治疗的潜在价值
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| 关 键 词： | 血液灌流 尿毒症毒物 壳聚糖 吸附剂 |
| 文章编号： | 1001-5493(2002)03-0193-06 |
| 修稿时间： | 2001年12月6日 |
INVESTIGATIONS ON THE ADSORPTION OF SOME UREMIC TOXINS BY CROSSLINKED CHITOSAN RESIN |
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| WANG Hong ZHANG Mingming YUAN Zhi,TENG Xinlian HE Binglin,The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation.INVESTIGATIONS ON THE ADSORPTION OF SOME UREMIC TOXINS BY CROSSLINKED CHITOSAN RESIN[J].Ion Exchange and Adsorption,2002,18(3):193-198. |
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| Authors: | WANG Hong ZHANG Mingming YUAN Zhi TENG Xinlian HE Binglin The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation |
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| Institution: | WANG Hong1 ZHANG Mingming1 YUAN Zhi1 TENG Xinlian2 HE Binglin1 1 The State Key Laboratory of Functional Polymer Materials for Adsorption and Separation, Institute of Polymer Chemistry,Nankai University,Tianjin 300071 2 Department of Chemistry,Nan |
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| Abstract: | Glutaraldehyde-crosslinked chitosan beads, which served as an adsorbent in the haemoperfusion process, were prepared using reversed-phase suspension method. After being treated with NaBH4 for a higher chemical stability, these chitosan beads were put to use in the adsorption treatment upon some uremic toxins in vitro. The data attained from the experiments showed that the prepared adsorbent exerted adsorption upon the carefully chosen targets, and the process of adsorption reached the equilibrium in a qualified short time. But the adsorption capacities of this adsorbent to the uremic toxins were quite different, and demonstrated a gradually increased tendency upon the small molecular toxins in a sequence of creatinine, uric acid and urea. For ACTH, a middle molecular uremic toxin, the adsorbent behaved the best, gained a highest saturated capacity, 13.04mg/g. |
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| Keywords: | Haemoperfusion Uremic toxins Chitosan Adsorbent |
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