Syntheses,characterization, and antimicrobial properties of nickel(II) dithiocarbamate complexes containing NiS4 and NiS2PN moieties |
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| Authors: | Damian C Onwudiwe Anthony C Ekennia Eric Hosten |
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| Institution: | 1. Faculty of Agriculture, Science and Technology, Material Science Innovation and Modelling (MaSIM) Research Focus Area, North-West University (Mafikeng Campus), Mmabatho, South Africa;2. Faculty of Agriculture, Science and Technology, Department of Chemistry, School of Mathematical and Physical Sciences, North-West University (Mafikeng Campus), Mmabatho, South AfricaDamian.Onwudiwe@nwu.ac.za;4. Department of Chemistry, Federal University, Ndufu-Alike Ikwo, Nigeria;5. Department of Chemistry, Nelson Mandela Metropolitan University, Port Elizabeth, South Africa |
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| Abstract: | Three Ni(II) dithiocarbamate complexes, Ni(buphdtc)2] (1), Ni(buphdtc)(PPh3)(NCS)] (2) and Ni(buphdtc)(PPh3)(NC)] (3) (where bu = butyl and ph = phenyl), were synthesized and characterized by elemental analysis, UVvis, and FTIR spectroscopies. Complexes 1 and 2 were further characterized by single-crystal X-ray structural analysis. The single-crystal X-ray structural analysis indicates a slightly distorted square planar geometry. In 2 and 3, the influences of the auxiliary ligands (PPh3, NCS, and NC) on their steric and electronic properties were observed. Thermal studies of the complexes showed decomposition starting at 250–300 °C, leading to formation of nickel sulfide phases around 400 °C. The complexes were screened against some bacteria strains, Staphylococcus aureus, Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Klebsiella oxytoca and Pseudomonas aeruginosa, and two fungi species, Aspergillus niger and Fusarium oxysporum. The complexes showed moderate-to-strong antimicrobial potentials, with Ni(buphdtc)2] (1) displaying the best antimicrobial activity. Fluconazole and streptomycin were used as reference drugs for antifungal and antibacterial assays, respectively. |
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| Keywords: | Nickel(II) complexes X-ray crystal structure thermal stability antimicrobial properties |
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