Synthesis,structure, and biological evaluation of three Cu(II) and Ni(II) (E)-3-(3,4-dimethoxyphenyl)acrylate complexes with organic diamines as potential urease inhibitors

Three new complexes (1–3) have been synthesized and characterized by X-ray single crystal determination and evaluated for inhibitory activity on jack bean urease. All the complexes contained a new cinnamic acid derivative as the ligand (C₁₁H₁₂O₄), (E)-3-(3,4-dimethoxyphenyl)acrylic acid, and crystallized in monoclinic C2/c space group. Complex 1 (C₁₁H₁₁O₄)₄(C₃N₂H₈)₂Cu₂ (C₃N₂H₈?=?1,2-diaminopropane) was obtained with a?=?20.488(2), b?=?19.596(2), c?=?15.2500(13), β?=?93.502(2)°, V?=?6111.2(10)?ų, Z?=?4, R ₁ ?=?0.0616, and wR ₂ ?=?0.2059. Complex 2 (C₁₁H₁₁O₄)₄(C₃N₂H₈)₂Cu₂ (C₃N₂H₈=1,3-diaminopropane) was obtained with a?=?20.2494(12), b?=?19.5732(12), c?=?14.8940(8), β?=?96.884(2)°, V?=?5860.6(6)?ų, Z?=?4, R ₁ ?=?0.0409, and wR ₂ ?=?0.1107. Complex 3 (C₁₁H₁₁O₄)₂(C₂N₂H₆)₂Ni₂·H₂O (C₂N₂H₆?=?ethylenediamine) was obtained with a?=?28.359(2), b?=?6.5422(5), c?=?16.8587(14), β?=?101.359(2)°, V?=?3066.5(4)?ų, Z?=?4, R ₁ ?=?0.0422, and wR ₂ ?=?0.1190. It was found that copper(II) complexes 1 IC₅₀?=?4.71?μM] and 2 IC₅₀?=?3.15?μM] showed strong inhibitory activity against jack bean urease compared with acetohydroxamic acid IC₅₀?=?10.01?μM] as a positive reference. Unfortunately, 3 exhibited no inhibitory activity.