Synthesis of 5-[2-(Phenoxy)ethyl] Derivatives of 6-Methyluracil, 6-Methyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one,and 2-Imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one |
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Authors: | M S Novikov A A Ozerov O G Sim |
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Institution: | (1) Research Institute of Pharmacology, Volgograd State Medical University, Volgograd, 400131, Russia |
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Abstract: | A synthesis of novel derivatives of 6-methyluracil, 6-methyl-2-thioxo-, and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one
containing a 2-(phenoxy)ethyl substituent at position 5 of the pyrimidine ring has been carried out. It was found that 5-2-(phenoxy)ethyl]
derivatives of 6-methyl-2-thioxo- and 2-imino-6-methyl-2,3-dihydro-1H-pyrimidin-4-one are obtained by the condensation of
the corresponding ethyl 3-oxo-2-(2-phenoxyethyl)butanoates with thiourea or guanidine. 6-Methyl-5-2-(phenoxy)ethyl]uracils
can be prepared by treating 6-methyl-5-2-(phenoxy)ethyl]-2-thioxo-2,3-dihydro-1H-pyrimidin-4-ones with an excess of aqueous
monochloroacetic acid solution.
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Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 8, pp. 1213–1217, August, 2005. |
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Keywords: | 2-imino-6-methyl-5-[2-(phenoxy)ethyl]-2 3-dihydro-1H-pyrimidin-4-ones 6-methyl-2-thioxo-5-[2-(phenoxy)ethyl]-2 3-dihydro-1H-pyrimidin-4-ones 6-methyl-5-[2-(phenoxy)ethyl]-2 3-dihydro-1H-pyrimidin-4-ones synthesis |
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