Synthesis of 5-Phenyl-7-trifluoromethyl-2,3-dihydroimidazo[1,2-a]pyridines |
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| Authors: | E Suloeva M Yure E Gudriniece S Belyakov M Petrova I Kalnite |
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| Institution: | (1) Riga Technical University, LV-1048 Riga, Latvia;(2) Latvian Institute of Organic Synthesis, LV-1006 Riga, Latvia |
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| Abstract: | Syntheses are reported for a series of 2-alkylamino-6-phenyl-4-trifluoromethylpyridines. The reaction of 3-cyano-2-(hydroxyalkylamino)-6-phenyl-4-trifluoromethylpyridines with thionyl chloride gave the corresponding 2-(chloroalkylamino)pyridines, 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydro-imidazo1,2-a]pyridines, and 9-cyano-6-phenyl-8-trifluoromethyl-2,3,4-trihydropyrido1,2-a]-pyrimidines. X-ray diffraction structural analysis was used to study 8-cyano-5-phenyl-7-trifluoromethyl-2,3-dihydroimidazo1,2-a]pyridine. |
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| Keywords: | 2 3-dihydroimidazo[1 2-a]pyridines 2 3 4-trihydropyrido[1 2-a]pyrimidines X-ray structural analysis |
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