| 聚酰胺-大孔树脂纯化海棠花中总黄酮及其抗肿瘤活性研究 |
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| 引用本文： | 卫强,徐飞,邱镇,纪小影.聚酰胺-大孔树脂纯化海棠花中总黄酮及其抗肿瘤活性研究[J].化学研究与应用,2015,27(4):435-440. |
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| 作者姓名： | 卫强 徐飞 邱镇 纪小影 |
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| 作者单位： | 安徽新华学院药学院,安徽合肥,230088 |
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| 基金项目： | 国家大学生创新创业训练项目(201412216008,201412216009)资助;安徽省大学生创新创业训练项目(AH201412216010)资助 |
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| 摘 要： | 采用聚酰胺-大孔树脂联用技术纯化海棠花总黄酮成分,检测总黄酮对小鼠S-180肉瘤的抑制作用。选择提取液-聚酰胺(g/g,1∶1)拌匀,低温烘干,加入NKA-9大孔树脂柱,树脂-提取液(g/g,10∶2)上柱(柱径高比1∶10),以水洗脱至无色,再以60%乙醇洗脱,洗脱液收集量为10BV,总黄酮纯度达85.96%。海棠花总黄酮体外抗肿瘤活性显示,当剂量为50mg·kg-1时,抑瘤率达44.28%,并可显著提高小鼠的胸腺指数和脾脏指数。
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| 关 键 词： | 海棠花 SFE-CO2萃取总黄酮 聚酰胺-大孔树脂联用 抗肿瘤 |
Study on purifying total flavones from malus halliana koehne with polyamide and macroporous resin and their antitumor activities |
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| WEI Qiang
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XU Fei
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QIU Zhen
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JI Xiao-ying.Study on purifying total flavones from malus halliana koehne with polyamide and macroporous resin and their antitumor activities[J].Chemical Research and Application,2015,27(4):435-440. |
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| Authors: | WEI Qiang XU Fei QIU Zhen JI Xiao-ying |
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| Institution: | WEI Qiang;XU Fei;QIU Zhen;JI Xiao-ying;Pharmacology college,Anhui Xin Hua University; |
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| Abstract: | |
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| Keywords: | malus halliana koehne total flavones extracted by SFE-CO2 combination macroporous resin with polyamide antitumor |
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