| 近红外光谱测定复方对乙酰氨基酚片的有效成分 |
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| 引用本文： | 蒋雪,陈泽琴,郭嘉伟,谢洪平.近红外光谱测定复方对乙酰氨基酚片的有效成分[J].化学研究与应用,2007,19(11):1255-1257. |
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| 作者姓名： | 蒋雪 陈泽琴 郭嘉伟 谢洪平 |
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| 作者单位： | 1. 苏州大学药学院,江苏,苏州,215123
2. 西华师范大学化学化工学院,四川,南充,637000 |
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| 基金项目： | 国家重点实验室基金
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苏州大学校科研和教改项目 |
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| 摘 要： | 复方对乙酰氨基酚是临床上常用的解热镇痛药,常用剂型有片剂和注射剂,其片剂含有对乙酰氨基酚、阿司匹林和咖啡因等三种有效成分。对于该制剂的质量控制,《中国药典》1]利用分光光度法测定对乙酰氨基酚的含量,用氢氧化钠标准溶液、高氯酸标准溶液分别滴定阿司匹林和咖啡因从而
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| 关 键 词： | 复方对乙酰氨基酚片 近红外光谱 偏最小二乘法 对乙酰氨基酚 阿司匹林 咖啡因 |
| 文章编号： | 1004-1656（2007）11-1255-03 |
| 收稿时间： | 2007-01-25 |
| 修稿时间： | 2007-04-26 |
Determinations of the effective components in compound paracetamol based on near infrared spectroscopy |
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| JIANG Xue,CHEN Ze-qin,GUO Jia-Wei,XIE Hong-ping.Determinations of the effective components in compound paracetamol based on near infrared spectroscopy[J].Chemical Research and Application,2007,19(11):1255-1257. |
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| Authors: | JIANG Xue CHEN Ze-qin GUO Jia-Wei XIE Hong-ping |
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| Institution: | 1. College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China; 2. College of Chemistry and Chemical Engineering, China West Normal University, Nangchong 637000, China |
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| Abstract: | Based on the near infrared diffuse reflectance spectroscopy,the analytical methods of the fast and simultaneous determinations for asipilin,paracetamol and caffeine contained in the compound paracetamol have been built by the partial least squares method.For the three drug components asipilin,paracetamol and caffeine,the correlation coefficients 0.9994,0.9903 and 0.9994 have been obtained,the root mean square errors(RMSE) of the calibration samples were 0.313,0.520 and 0.0301,and the RMSE-s of the prediction samples were 1.07,0.464 and 0.309,respectively. |
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| Keywords: | compound paracetamol near infrared diffuse reflectance spectroscopy partial least squares asipilin paracetamol caffeine |
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