| 对-二甲氨甲基杯[8]芳烃与DNA相互作用的紫外-可见光谱 |
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| 引用本文： | 黄志兵,李来生,王宇晓,刘旭,谢冰.对-二甲氨甲基杯[8]芳烃与DNA相互作用的紫外-可见光谱[J].化学研究与应用,2004,16(6):808-810. |
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| 作者姓名： | 黄志兵 李来生 王宇晓 刘旭 谢冰 |
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| 作者单位： | 南昌大学分析测试中心,江西,南昌,330047;南昌大学分析测试中心,江西,南昌,330047;南昌大学分析测试中心,江西,南昌,330047;南昌大学分析测试中心,江西,南昌,330047;南昌大学分析测试中心,江西,南昌,330047 |
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| 基金项目： | 江西省教委资助项目(JJ2003 73 16)，江西省自然科学基金资助项目(9920024) |
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| 摘 要： | 被称为“第三代超分子化合物”的杯芳烃，是一类对位烷基苯酚与甲醛缩合的寡聚大环化合物，许多实验证实杯芳烃能通过超分子作用识别客体，这种方式类同于DNA与小分子的作用，
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| 关 键 词： | 紫外光谱法 光谱探针 水溶性杯芳烃 对-二甲氨甲基杯[8]芳烃 小牛胸腺DNA |
| 文章编号： | 1004-1656(2004)06-0808-03 |
| 修稿时间： | 2003年10月8日 |
Study on the interaction of water-soluble p-(N,N-Dimethylamino-methyl)calix[8]arene with DNA by ultraviolet-visible spectrometry |
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| HUANG Zhi-bing,LI Lai-sheng,WANG Yu-xiao,LIU Xu,XIE Bing.Study on the interaction of water-soluble p-(N,N-Dimethylamino-methyl)calix[8]arene with DNA by ultraviolet-visible spectrometry[J].Chemical Research and Application,2004,16(6):808-810. |
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| Authors: | HUANG Zhi-bing LI Lai-sheng WANG Yu-xiao LIU Xu XIE Bing |
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| Institution: | HUANG Zhi-bing,LI Lai-sheng~*,WANG Yu-xiao,LIU Xu,XIE Bing |
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| Abstract: | The interaction of water-soluble P-(N,N-dimethylaminomethyl)-calix8]arene(CX8)with calf thymus DNA was studied using neutral red(NR) as a probe by uv-vis spectroscopy.The effect factors such as the pH of solution and ionic strength on the spectra were also investigated.The interaction mechanism was proposed.The results show that the strong electrostatic interaction between DNA and CX8 existed,on the one hand,the oxyphosphate anion of DNA can be neutralized by CX8 partally,which induced the contraction of DNA and the conformational change of DNA,which led to release NR from NDA partially.On the other hand,the CX8 can also compete the electrostatic sites with NR directly. |
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| Keywords: | UV spectroscopy spectroscopic probe water-soluble calixarenes P-(N N-dimethyl-aminomethyl)-calix[8]arene calf thymus DNA |
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