| 抗肝片吸虫病药物化合物的合成及解偶联活性研究 |
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| 引用本文： | 王晓晶,陈静.抗肝片吸虫病药物化合物的合成及解偶联活性研究[J].化学研究与应用,1999,11(4):422-424. |
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| 作者姓名： | 王晓晶 陈静 |
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| 作者单位： | 内蒙古大学化学系!呼和浩特010021陈静，内蒙古大学化学系!呼和浩特010021，内蒙古大学化学系!呼和浩特010021，内蒙古大学化学系!呼和浩特010021，内蒙古大学化学系!呼和浩特010021 |
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| 摘 要： | 肝片吸虫是传播极为广泛的家畜体内寄生虫。文献报道N(2,4,5三氯)苯基2羟基3,5,6三氯苯磺酰胺(简称为HBSA)及其卤化衍生物是比较好的治疗肝片吸虫病药物,部分化合物已获美国专利1]。经我们近几年对苯磺酰苯胺类化合物药物作用机理的研究初步证实:该类化合物是线粒体氧化...
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| 关 键 词： | 肝片吸虫 N-(取代苯乙氰基)苯基-2-羟基-取代苯磺酰胺 合成 解偶联 杀虫活性 |
SYNTHESIS OF THE DRUG COMPOUNDS AGAINST PARASITE FASCIOLA HEPATICA AND STUDY ON THE UNCOUPLING ACTIVITY |
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| Wang Xiaojing,Chen Jing,Zhao Jun,Li Zhe,Xin Min.SYNTHESIS OF THE DRUG COMPOUNDS AGAINST PARASITE FASCIOLA HEPATICA AND STUDY ON THE UNCOUPLING ACTIVITY[J].Chemical Research and Application,1999,11(4):422-424. |
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| Authors: | Wang Xiaojing Chen Jing Zhao Jun Li Zhe Xin Min |
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| Abstract: | The substituted 2 hydroxylbenzenesulfonanilides compounds have been synthesized.The decoupling action of these compounds for oxidative phosphorylation in rat liver mitochondria were studied.Decoupling activities were measured by measuring stimulation of state 4 respiration and measuring the increase of Pi in reaction medium. |
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| Keywords: | parasite fasciola hepatica substituted 2 hydroxylbenzenesulfo nanilides syntheses uncoupling fasciolicidal activity |
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